衣原体脂质代谢研究进展  

Advances in lipid metabolism during Chlamydia infection

作　　者：陈立芳 张荣荣 贾天军[1,2] Chen Lifang;Zhang Rongrong;Jia Tianjun(Institute of Pathogenic Biology and Immunology,Hebei Northern University,Zhangjiakou 075000,China;Key Laboratory of Clinical Laboratory Diagnostics,School of Medical Laboratory,Hebei Northern University,Zhangjiakou 075000,China)

机构地区：[1]河北北方学院病原生物学与免疫学研究所,张家口075000 [2]河北北方学院医学检验学院临床检验诊断学重点实验室,张家口075000

出　　处：《中华微生物学和免疫学杂志》2021年第6期479-483,共5页Chinese Journal of Microbiology and Immunology

基　　金：河北省自然科学基金(C2020405014)。

摘　　要：衣原体是一种革兰氏阴性的专性细胞内病原体,是人类生殖道、眼和呼吸道感染的重要原因。它在一种被称为包涵体的专门膜结合区室中复制,并通过分泌的效应子在宿主的敌对细胞内环境中存活,但需要宿主衍生的脂质才能在细胞内生长和发育。新兴证据表明衣原体已经进化出多种策略,通过与宿主细胞区室相互作用,将运输途径重定向到其细胞内利基来满足其脂质需求。本文就衣原体获取宿主脂质的途径及其代谢机制展开简要叙述。Chlamydia,a gram-negative obligate intracellular pathogen,is a major cause of human reproductive tract,eye and respiratory tract infections.It replicates in a special membrane-binding chamber called inclusion and survives in the host′s hostile intracellular environment through secreting effectors,but requires host-derived lipids to grow and develop in the cells.Emerging evidences suggest that Chlamydia has evolved a variety of strategies to meet its lipid needs by interacting with host cell compartments and redirecting the transport pathway to its intracellular niche.This paper briefly described the pathway for obtaining host lipids and the mechanism of lipid metabolic during Chlamydia infection.

关 键 词：衣原体 磷脂 胆固醇 

分 类 号：R374[医药卫生—病原生物学]