中枢性呼吸暂停在儿童阻塞性睡眠呼吸暂停综合征中分布特征研究  

Distribution of central sleep apnea in children with obstructive sleep apnea hypopnea syndrome

作　　者：崔菲菲[1] 陈超[1] 刘静 常丽[1] CUI Fei-fei;CHEN Chao;LIU Jing(Department of Respiratory Medicine,the Children's Hospital Affiliated to the Capital Institute of Pediatrics,Beijing 100020,China)

机构地区：[1]首都儿科研究所附属儿童医院呼吸睡眠中心,北京100020

出　　处：《中国实用儿科杂志》2021年第6期459-462,共4页Chinese Journal of Practical Pediatrics

摘　　要：目的研究中枢性呼吸暂停(CSA)在儿童阻塞性睡眠呼吸暂停综合征(OSAHS)中的分布特征。方法选择2017年1月至2018年3月在首都儿科研究所附属儿童医院呼吸睡眠监测中心完善整夜呼吸睡眠监测的患儿,通过多导睡眠呼吸监测(PSG)结果将患儿分为OSAHS组和非OSAHS组,OSAHS组又分为轻度、中度、重度OSAHS组。比较各组间患儿中枢性呼吸暂停指数(CAI)的差异,观察OSAHS患儿CAI和呼吸暂停低通气指数(AHI)、阻塞性呼吸暂停指数(OAI)及年龄的相关性并进行分析。结果入组患儿194例,男117例(60.3%),女77例(39.7%),年龄(5.7±3.0)岁。AHI的M值(Q1,Q3)为6.5(3.9,12.0),CAI的M值(Q1,Q3)为1.0(0.4,2.0)。(1)所有入组患儿的CAI与AHI呈正相关(相关系数为r=0.329,P<0.05)、CAI与OAI呈正相关(r=0.243,P<0.05);CAI与患儿年龄呈负相关(r=-0.289,P<0.05)。(2)OSAHS组123例,非OSAHS组71例,OSAHS组CAI均高于非OSAHS组,差异有统计学意义(P<0.05);且随着AHI增加,CAI有增加趋势(P趋势<0.001);OSAHS组不同年龄组CAI存在差异,随着年龄增加,CAI减少。(3)OSAHS组患儿CAI与AHI呈正相关(r=0.307,P<0.01)、CAI与OAI呈正相关(r=0.378,P<0.01)、CAI与年龄呈负相关(r=-0.362,P<0.01)。结论 OSAHS组患儿CAI高于非OSAHS组;OSAHS组患儿CAI和OAI并存,并呈正相关;OSAHS组患儿病情轻重和年龄是OSAHS患儿CAI的影响因素。Objective To study the distribution of central sleep apnea(CSA)in children with obstructive sleep apnea hypopnea syndrome(OSAHS).Methods From January 2017 to March 2018,the children who had completed the whole night respiratory sleep monitoring in the Respiratory and Sleep Monitoring Center of our hospital were enrolled. The children were divided into OSAHS and non-OSAHS groups by the PSG. The OSAHS group was divided into mild,medium and severe OSAHS groups. The differences in central apnea index(CAI)among the groups were compared,and the correlation of CAI with AHI,OAI and age were analyzed.ResultsTotally 194 children were enrolled in the study,including 117 males(60.3%),and 77 females(39.7%),with an average age of(5.7±3.0)years old. The M(Q1,Q3)of AHI was 6.5(3.9,12),and CAI’s M(Q1,Q3)was 1.0(0.4,2.0).(1)The CAI and AHI of all the children in the study were positively correlated(the correlation coefficient was r=0.329,P<0.05),and CAI was positively correlated with OAI(r=0.243,P<0.05);CAI was negatively correlated with the age of the children(r=-0.289,P<0.05).(2)There were 123 children in OSAHS group and 71 in non-OSAHS group. The CAI of the children in OSAHS group was higher than that of non-OSAHS group(P<0.05). With the increase of AHI,CAI increased(P trend<0.001).There were significant differences in CAI in different age groups in OSAHS group,and CAI decreased with the increase of age.(3)There was a positive correlation between CAI and AHI(r=0.307,P<0.01),and between CAI and OAI(r=0.378,P<0.01),while CAI was negatively correlated with age(r=-0.362,P<0.01).Conclusion The CAI of OSAHS group is higher than that of non-OSAHS group. The CAI and OAI coexist in OSAHS group,and there is a positive correlation between them. The disease severity and the age of the patients in OSAHS group are the influencing factors of CAI in OSAHS children.

关 键 词：中枢性呼吸暂停指数 阻塞性睡眠呼吸暂停低通气综合征 儿童多导睡眠呼吸监测 

分 类 号：R72[医药卫生—儿科]