Rubicon: a facilitator of viral immune evasion  

作　　者：Peining Fang Haisheng Yu Mengqi Li Rui He Ying Zhu Shi Liu 

机构地区：[1]State Key Laboratory of Virology,Modern Virology Research Center,College of Life Sciences,Wuhan University,430072 Wuhan,China

出　　处：《Cellular & Molecular Immunology》2019年第9期770-771,共2页中国免疫学杂志（英文版）

摘　　要：In a study published in cellular and molecular immunology,Wan et al.demonstrate a new mechanism of viral immune evasion.1 It was observed that Rubicon,the RUN domain Beclin-1-interacting and cysteine-rich domain-containing protein,is induced by viral infection and antagonizes interferon(IFN)production,thereby facilitating viral replication.This study not only demonstrates a direct link between Rubicon and NF-κB essential modulator(NEMO),but also demonstrates how the interaction between Rubicon and NEMO inhibits the production of type I interferon.This study shows a previously unrecognized function of Rubicon as an important negative regulator of the innate immune response.

关 键 词：thereby MODULATOR response. 

分 类 号：F42[经济管理—产业经济]