Antifungalmycin,an antifungal macrolide from Streptomyces padanus 702  

作　　者：Yi-Fen WANG Sai-Jin WEI Zhi-Ping ZHANG Tong-He ZHAN Guo-Quan TU 

机构地区：[1]State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201,China [2]China Biological Science and Engineering College of Jiangxi Agriculture University,Nanchang Key Laboratory of Fermentation Application Technology,Nanchang 330045,China

出　　处：《Natural Products and Bioprospecting》2012年第1期41-45,共5页应用天然产物（英文）

摘　　要：Two polyene macrolide antibiotics:antifungalmycin(1)and fungichromin(2)were isolated from the culture mycelia of Streptomyces padanus 702 via bioactivity-guided fractionation using various chromatographic procedures.Their structures were elucidated on the basis of spectral analysis,and 1 is a new polyene macrolide.Compounds 1 and 2 showed significant inhibition against Gibberella zeae with EC_(50)values of 26.71 and 2.21μg/mL,Fusicoccum sp.(plantain head blight)with EC_(50)values of 23.4 and 3.17μg/mL,Mucor ssp.8894 with EC_(50)values of 28.80 and 2.11μg/mL,Ustilaginoidea virens with EC_(50)values of 26.72 and 0.21μg/mL,respectively.This shows that the microbial secondary metabolites 1 and 2 have the potential to be developed as agricultural fungicides for use against G.zeae,Fusicoccum sp.,Mucor ssp.8894,and U.virens.

关 键 词：antifungalmycin Streptomyces padanus 702 polyene macrolide BIOCONTROL antifungal activity PHYTOPATHOGEN 

分 类 号：O62[理学—有机化学]