Five new polyketides from the basidiomycete Craterellus odoratus  

作　　者：Hua GUO Tao FENG Zheng-Hui LI Ji-Kai LIU 

机构地区：[1]State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201,China [2]School of Chemistry and Life Science,Anshan Normal College,Anshan 114005,China [3]Graduate University of Chinese Academy of Sciences,Beijing 100049,China

出　　处：《Natural Products and Bioprospecting》2012年第4期170-173,共4页应用天然产物（英文）

基　　金：supported by National Basic Research Program of China(973 Program,2009CB522300);the National Natural Science Foundation of China(30830113,U1132607).

摘　　要：Five new polyketides,craterellones A-E(1-5),were isolated from cultures of basidiomycete Craterellus odoratus,together with five known compounds(6-10).Structures of 1-5 were elucidated on the basis of extensive spectroscopic analysis.All compounds were evaluated for their inhibitory activities against one isozyme of 11β-hydroxysteroid dehydrogenase(11β-HSD1)and cytotoxic activities on five tumor cell lines.Compound 10 exhibited significant cytotoxicity against HL-60,SMMC-7721,A-549,MCF-7,and SW-480,with IC50 values of 0.50,0.69,0.64,1.10,0.54μM,respectively.

关 键 词：Craterellus odoratus craterellones POLYKETIDES 

分 类 号：R73[医药卫生—肿瘤]