广西巴马与湖南石门献浆者动脉粥样硬化性心血管疾病相关指标状况比较  

ASCVD indexes in Bama and Shimen area plasma donors,China

作　　者：张容[1] 王宗奎[1] 张巍 刘凤娟[1] 叶生亮[1] 杜晞[1] 曹海军[1] 马莉[1] 李长清[1] ZHANG Rong;WANG Zongkui;ZHANG Wei;LIU Fengjuan;YE Shengliang;DU Xi;CAO Haijun;MA Li;LI Changqing(Institute of Blood Transfusion,Chinese Academy of Medical Sciences and Peking Union Medical College,Chengdu 610052,China)

机构地区：[1]中国医学科学院北京协和医学院输血研究所,四川成都610052

出　　处：《中国输血杂志》2021年第6期634-638,共5页Chinese Journal of Blood Transfusion

基　　金：四川省科学技术厅项目(2019YFS0308,2019YFH0018);中国输血协会威高科研基金资助项目(CSBT-WG-2017-07)。

摘　　要：目的了解长寿地区献浆人群中动脉粥样硬化性心血管疾病相关指标水平及影响因素。方法随机选取2018年611月1 027名长寿地区(广西巴马)及1 816名非长寿地区(湖南石门)献浆者,检测其甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDLC)、低密度脂蛋白胆固醇(LDLC)、载脂蛋白A1(Apo-A1)、载脂蛋白B(Apo-B)及果糖胺(FUN),并对两组的检测结果进行统计分析。结果与非长寿区组相比,长寿区组TG、TC及FUN水平降低(1.41±0.96 vs 2.31±1.28, 3.89±0.92 vs 4.04±0.82, 176.65±26.60 vs 200.33±34.19;均P<0.05),HDLC、LDLC、Apo-A1及Apo-B水平升高(1.11±0.32 vs 0.96±0.25, 2.53±0.70 vs 2.29±0.56, 1.56±0.28 vs 1.23±0.18, 0.80±0.27 vs 0.72±0.19;均P<0.05);长寿区组高TG(12.07%vs 40.01%)、低HDLC(24.63%vs 43.90%)、低Apo-A1(1.66%vs 22.56%)及高FUN(0.58%vs 2.48%)检出率较低,高LDLC(2.73%vs 0.28%)及高Apo-B(4.09%vs 0.22%)检出率较高(P<0.05)。长寿区献浆人群TC、HDLC、LDLC、Apo-A1及Apo-B水平在不同年龄组中存在差异(P<0.05)且与年龄正相关;性别及民族差异对TC、HDLC、LDLC、Apo-A1及Apo-B水平影响较大;血型对各指标水平影响较小。结论长寿地区(广西巴马)献浆者动脉粥样硬化性心血管疾病相关指标水平与非长寿地区(湖南石门)均有一定差异,且长寿地区(广西巴马)献浆者的年龄、民族、性别及血型对以上指标水平均有一定影响。Objective To investigate the level of atherosclerotic cardiovascular disease(ASCVD) related indexes in plasma donors from longevity area, and explore its influencing factors. Methods 1 027 plasma donors from longevity hotspot(Bama, Guangxi province) and 1 816 donors from non-longevity region(Shimen, Hunan province) who donated plasma during June to November 2018 were randomly selected. Triglyceride(TG), total cholesterol(TC), high-density lipoprotein cholesterol(HDLC), low density lipoprotein cholesterol(LDLC), apolipoprotein A1(Apo-A1), apolipoprotein B(Apo-B), and fructosamine(FUN) of the two groups were measured and statistically analyzed. Results Compared with the non-longevity region group, the TG, TC and FUN levels of longevity hotspot group were lower(1.41±0.96 vs 2.31±1.28, 3.89±0.92 vs 4.04±0.82, 176.65±26.60 vs 200.33±34.19;all P<0.05), but HDLC, LDLC, Apo-A1 and Apo-B levels were higher(1.11±0.32 vs 0.96±0.25, 2.53±0.70 vs 2.29±0.56, 1.56±0.28 vs 1.23±0.18, 0.80±0.27 vs 0.72±0.19;all P<0.05). The yield(%) of high TG(12.0 vs 40.01) and FUN(0.58 vs 2.48), low HDLC(24.63 vs 43.90) and Apo-A1(1.66 vs 22.56) were lower in longevity area than those in non-longevity region(all P<0.05), but high LDLC(2.73 vs 0.28) and Apo-B(4.09 vs 0.22) yield(%) were higher in longevity area group( P<0.05).The levels of TC, HDLC, LDLC, Apo-A1 and Apo-B were significantly different by ages(all P < 0.01), presenting positively correlated with age, significantly by gender and nationality, and slightly by blood type.Conclusion The ASCVD indexes of plasma donors from Bama were different from those from Shimen. Age, nationality, gender and blood type of donors from Bama all had a certain influence on these indexes levels.

关 键 词：长寿地区 献浆者 动脉粥样硬化性心血管疾病指标 

分 类 号：R457.1[医药卫生—治疗学] R714.252[医药卫生—临床医学]