Hepatitis delta virus: From infection to new therapeutic strategies  

作　　者：Grazia A Niro Arianna Ferro Francesca Cicerchia Isabella Brascugli Marilena Durazzo 

机构地区：[1]Department of Gastroenterology,IRCCS Casa Sollievo della Sofferenza Hospital Foundation,San Giovanni Rotondo 71013,Italy [2]Department of Medical Sciences,University of Turin,Turin 10126,Italy

出　　处：《World Journal of Gastroenterology》2021年第24期3530-3542,共13页世界胃肠病学杂志（英文版）

摘　　要：The hepatitis delta virus(HDV)is a small RNA virus that encodes a single protein and which requires the hepatitis B virus(HBV)-encoded hepatitis B surface antigen(HBsAg)for its assembly and transmission.HBV/HDV co-infections exist worldwide and show a higher prevalence among selected groups of HBV-infected populations,specifically intravenous drug users,practitioners of high-risk sexual behaviours,and patients with cirrhosis and hepatocellular carcinoma.The chronic form of HDV-related hepatitis is usually severe and rapidly progressive.Patterns of the viral infection itself,including the status of co-infection or super-infection,virus genotypes(both for HBV and HDV),and persistence of the virus’replication,influence the outcome of the accompanying and manifested liver disease.Unfortunately,disease severity is burdened by the lack of an effective cure for either virus type.For decades,the main treatment option has been interferon,administered as mono-therapy or in combination with nucleos(t)ide analogues.While its efficacy has been reported for different doses,durations and courses,only a minority of patients achieve a sustained response,which is the foundation of eventual improvement in related liver fibrosis.The need for an efficient therapeutic alternative remains.Research efforts towards this end have led to new treatment options that target specific steps in the HDV life cycle;the most promising among these are myrcludex B,which inhibits virus entry into hepatocytes,lonafarnib,which inhibits farnesylation of the viral-encoded LHDAg large hepatitis D antigen,and REP-2139,which interferes with HBsAg release and assembly.

关 键 词：Hepatitis delta virus Hepatitis B virus Myrcludex LONAFARNIB REP 2139 

分 类 号：R512.64[医药卫生—内科学]