Chances and risks of sodium-glucose cotransporter 2 inhibitors in solid organ transplantation:A review of literatures  

作　　者：Marlene Schwarzenbach Flavia Elena Bernhard Cecilia Czerlau Daniel Sidler 

机构地区：[1]Department of Nephrology and Hypertension,University Hospital Insel Bern,Bern 3010,Switzerland

出　　处：《World Journal of Transplantation》2021年第7期254-262,共9页世界移植杂志

摘　　要：Solid organ transplantation offers life-saving treatment for patients with endorgan dysfunction.Patient survival and quality of life have improved over the past few decades as a result of pharmacological development,expansion of the donor pool,technological advances and standardization of practices related to transplantation.Still,transplantation is associated with cardiovascular complications,of which post-transplant diabetes mellitus(PTDM)is one of the most important.PTDM increases mortality,which is best documented in patients who have received kidney and heart transplants.PTDM results from traditional risk factors seen in patients with type 2 diabetes mellitus,but also from specific posttransplant risk factors such as metabolic side effects of immunosuppressive drugs,post-transplant viral infections and hypomagnesemia.Oral hypoglycaemic agents are the first choice for the treatment of type 2 diabetes mellitus in non-transplanted patients.However,the evidence on the safety and efficacy of oral hypoglycaemic agents in transplant recipients is limited.The favourable risk/benefit ratio,which is suggested by large-scale and long-term studies on new glucoselowering drug classes such as glucagon-like peptide 1 receptor agonists and sodium-glucose cotransporter 2 inhibitors,makes studies warranted to assess the potential role of these agents in the management of PTDM.

关 键 词：Solid organ transplantation Post-transplant diabetes mellitus Antidiabetic treatment Sodium-glucose cotransporter 2 inhibitors RENOPROTECTION 

分 类 号：R58[医药卫生—内分泌]