Two new tirucallane triterpenoids from Aphanamixis grandifolia  

作　　者：Xiao-Ying WANG Gui-Hua TANG Chun-Mao YUAN Yu ZHANG Li HOU Qing ZHAO Xiao-Jiang HAO Hong-Ping HE 

机构地区：[1]State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201,China [2]Faculty of Pharmacy,Yunnan University of TCM,Kunming 650500,China

出　　处：《Natural Products and Bioprospecting》2012年第5期222-226,共5页应用天然产物（英文）

基　　金：This work was financially supported by grants from the National Basic Research Program of China(973 Program,2009CB522300 and 2009CB940900);National Natural Science Funding of China(31170332);the Young Academic and Technical Leader Raising Foundation of Yunnan Province(2010CI047).

摘　　要：Two new tirucallane triterpenoids,2a-ethoxy-2,3-secotirucalla-2,29-epoxy-7-ene-23-oxo-3-oic acid(1)and(23E)-2a-hydroxytirucalla-7,23,25-triene-3-one(2),along with the known 2,3-secotirucalla-2,3;2,29-diepoxy-7-ene-3,23-dione(3),were isolated from the leaves and twigs of Aphanamixis grandifolia.Their structures were elucidated by extensive NMR and MS data,and compound 3 was further confirmed by X-ray crystal diffraction analysis.Antimicrobial activities and insecticidal activities of these three compounds were also evaluated.Compound 1 showed good antimicrobial activity against Staphylococcus aureus with the MIC value of 1.56μg/mL,while compounds 1 and 2 showed insecticidal activity at 100 ppm,with the corrected mortality 79.1%and 60.6%,respectively.

关 键 词：Aphanamixis grandifolia MELIACEAE 2 3-seco-tirucallane triterpenoid BIOASSAYS 

分 类 号：O62[理学—有机化学]