Two new neolignans from Manglietia insignis  

作　　者：Shan-Zhai SHANG Ju-Ming YAN Hai-Bo ZHANG Yi-Ming SHI Zhong-Hua GAO Xue DU Yan LI Wei-Lie XIAO Han-Dong SUN 

机构地区：[1]State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201,Yunnan,China [2]University of Chinese Academy of Sciences,Beijing 100049,China

出　　处：《Natural Products and Bioprospecting》2012年第5期227-230,共4页应用天然产物（英文）

基　　金：This project was supported financially by the NSFC(No.20802082 and 30830115);the projects from the Chinese Academy of Sciences(KSCX2-EW-Q-10 and KSCX1-YW-R-24);the Major State Basic Research Development Program of China(No.2009CB522300 and 2009CB940900);the Natural Science Foundation of Yunnan Province(2012FB178 and 20080A007);the project of recruited top talent of sciences and technology of Yunnan Province(2009C1120).

摘　　要：Two new neolignans,manneoinsigins A(1)and B(2),together with four known lignans,were isolated from the leaves and stems of Manglietia insignis.The new compounds were established on the basis of extensive spectroscopic analyses.All compounds except 2 were tested for their cytotoxic activity.Compound 3 showed weak cytotoxic activity against the HL-60 human tumor cell line with the IC50 value of 23.5μM.

关 键 词：MAGNOLIACEAE Manglietia insignis NEOLIGNAN cytotoxic activity 

分 类 号：O62[理学—有机化学]