Th2 polarization in target organs is involved in the alleviation of pathological damage mediated by transplanting granulocyte colony-stimulating factor-primed donor T cells  

作　　者：Yang Zhoui Leqing Cao Huidong Guo Yan Hong Ming Wang Ke Wang Xiaojun Huang Yingjun Chang 

机构地区：[1]Peking University People's Hospital,Peking University Institute of Hematology,National Clinical Research Center for Hematologic Disease,Beijing Key Laboratory of HSCT,Peking University,Beijing 100044,China [2]Peking-Tsinghua Center for Life Sciences,Academy for Advanced Interdisciplinaiy Studies,Peking University,Beijing 100044,China

出　　处：《Science China(Life Sciences)》2021年第7期1087-1096,共10页中国科学（生命科学英文版）

基　　金：partly supported by grants from the National Key Research and Development Program of China(2017YFA0104500);National Natural Science Foundation of China(81670168);the Key Program of National Natural Science Foundation of China(81230013)。

摘　　要：Acute graft-versus-host disease(a GVHD)is caused by allo-activated donor T cells infiltrating target organs.As a regulator of immune function,granulocyte colony-stimulating factor(G-CSF)has been demonstrated to relieve the a GVHD reaction.However,the role of G-CSF-primed donor Tcells in specific target organs is still unknown.In this study,we employed a classical MHC-mismatched transplantation mouse model(C57BL/6 into BALB/c)and found that recipient mice transplanted with GCSF-primed T cells exhibited prolonged survival compared with that of the PBS-treated group.This protective function against GVHD mediated by G-CSF-primed donor T cells was further confirmed by decreased clinical and pathological scores in this a GVHD mouse model,especially in the lung and gut.Moreover,we found that Tcells polarized towards Th2 cells and regulatory T cells were increased in specific target organs.In addition,G-CSF treatment inhibited inducible co-stimulator(ICOS)expression and increased the expression of tolerance-related genes in recipient mice.Our study provides new insight into the immune regulatory effects of G-CSF on T cell-mediated a GVHD,especially for its precise regulation in GVHD target organs.

关 键 词：granulocyte colony-stimulating factor graft-versus-host disease mouse model Th2 polarization 

分 类 号：R457.7[医药卫生—治疗学]