基于“脾-线粒体”相关理论探讨“化瘀祛痰、健脾化浊”法对高脂合并急性心肌梗死的防治作用  

Intervention of AMI from Regulation of Heart Mitochondria Function Based on Theory of Removing Blood Stasis and Eliminating Phlegm

作　　者：邰贺 姜晓琳[1] 贾连群[1] TAI He;JIANG Xiaolin;JIA Lianqun(Department of Key Laboratory of Ministry of Education for Traditional Chinese Medicine Visera-State Theory in Liaoning University Traditional Chinese Medicine,Shenyang 110847,Liaoning,China)

机构地区：[1]辽宁中医药大学中医脏象理论及应用教育部重点实验室,辽宁沈阳110847

出　　处：《中华中医药学刊》2021年第6期72-75,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金(81774022);辽宁省创新团队(LT2016012);兴辽英才计划项目(XLYC1902100);沈阳市科技计划(18-013-0-74)。

摘　　要："化瘀祛痰"法在中医心血管疾病(CVD)的防治中有着广泛的应用价值。现代医学研究显示:急性心肌梗死(AMI)是冠状动脉粥样硬化(AS)的一种急危重表现形式。高脂血症是诱发冠状动脉粥样硬化的重要诱因,影响冠状动脉粥样硬化性心脏病的发生、发展及其预后。痰湿内阻(标实)、气血瘀滞、气血虚(本虚)是AS的主要临床表现,现代医学中的胰腺、胃及其肝脏构成中医中的"脾"。线粒体是人体能量代谢的工厂,而脾气健运是保证线粒体功能的关键所在。"化瘀祛痰"法能很好地改善痰浊、脾虚而实现对AS的治疗,进而改善AMI后的心肌损伤。总结了大量的文献资料结合近年来课题组的研究结果,探讨以心肌细胞线粒体作为干预的靶点,探讨"化瘀祛痰"法对AMI的治疗及其预防作用。The method of "removing blood stasis and expelling phlegm" has a wide application value in the prevention and treatment of cardiovascular disease(CVD). Modern medical research shows that acute myocardial infarction(AMI) is a critical manifestation of coronary atherosclerosis(AS). Hyperlipemia is an important inducement of coronary atherosclerosis, which affects the occurrence, development and prognosis of arteriosclerosis. Phlegm-dampness internal obstruction(standard), Qi-blood stasis, Qi-blood deficiency(deficiency of origin) are the main clinical manifestations of AS. The mitochondria is the factory of energy metabolism, and a good temper is the key to guarantee the function of mitochondria. The method of "removing blood stasis and expelling phlegm" can improve phlegm and spleen deficiency and realize the treatment of AS, and then improve the myocardial injury after AMI. We summarized a lot of literature and combinedthe results of our research group in recent years to explore myocardial mitochondria as the intervention target and the "removing blood stasis and dispelling phlegm" method in the treatment and prevention of AMI.

关 键 词：化痰祛瘀 高脂血症 急性心肌梗死 线粒体 

分 类 号：R541.4[医药卫生—心血管疾病]