杞黄降糖胶囊对初发2型糖尿病临床疗效分析及对胰岛功能的影响  

Clinical Effect Analysis of Qihuang Jiangtang Capsule(杞黄降糖胶囊) on Primary Type 2Diabetes Mellitus and Its Effect on Islet Function

作　　者：腾佳丽 苏瑞瑞 刘鸿丽[1] 崔薇薇[1] 仉媛媛[1] 邹朝平 姜健阁[1] 刘杰军[1,2] TENG Jiali;SU Ruirui;LIU Hongli;CUI Weiwei;ZHANG Yuanyuan;ZU Chaoping;JIANG Jiange;LIU Jiejun(Dezhou Peoples Hospital,Dezhou 253014,Shando昭,China;Binzhou Medical University,Yantai 264003,Shandong,China)

机构地区：[1]德州市人民医院,山东德州253014 [2]滨州医学院,山东烟台264003

出　　处：《中华中医药学刊》2021年第6期236-239,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：山东省医药卫生科技发展计划(2017WS846)。

摘　　要：目的观察杞黄降糖胶囊对初发2型糖尿病患者的临床疗效及其对胰岛功能的影响。方法选取76例初发2型糖尿病患者,随机分为两组,观察组(39例)给予杞黄降糖胶囊治疗,对照组(37例)给予盐酸二甲双胍肠溶片治疗,均治疗12周,检测并记录两组患者治疗前后的空腹血糖(FPG)、餐后2 h血糖(PPG)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、糖化血红蛋白(HbA1c)等指标,并于治疗前后行葡萄糖耐量试验及胰岛素释放试验,计算胰岛素抵抗指数(HOMA-IR),并计算30 min胰岛素(30 minINS)与空腹胰岛素(FINS)差值(ΔI30)和30 min血糖(30 minPG)与空腹血糖(FPG)差值(ΔG30)的比值(ΔI30/ΔG30),即ΔI30/ΔG30=(I30-I0)/G30-G0),同时比较两组不良反应情况。结果两组患者治疗后,FPG、PPG、HbAlc、HOMA-IR等指标均明显下降(P<0.05),30 minFINS、ΔI30/ΔG30均明显上升(P<0.05);观察组治疗后的FPG、PPG、HbAlc、HOMA-IR、ΔI30/ΔG30等指标较对照组治疗后差异均没有统计学意义(P>0.05)。治疗前后,对照组及观察组的TC、TG、LDL-C水平均显著下降(P<0.05);观察组治疗后的LDL-C水平较对照组治疗后LDL-C水平低(P<0.05)。观察组胃肠道不良反应明显少于对照组(P<0.05)。结论杞黄降糖胶囊能有效降低初发2型糖尿病患者血糖、血脂水平,具有减轻胰岛素抵抗及改善胰岛功能的作用,且用药安全性高、不良反应少。Objective To observe the clinical effect of Qihuang Jiangtang Capsule(杞黄降糖胶囊) on patients with primary type 2 diabetes mellitus and its effect on islet function. Methods In our study, we enrolled 76 participants with type 2 diabetes mellitus at the beginning, and participants were randomly divided into two groups. The observation group was treated with Qihuang Jiangtang Capsule. The control group was treated with metformin. The treatment was lasted for 12 weeks. Participants in two groups were measured the fasting plasma glucose(FPG), 2-hour plasma glucose(PPG), total cholesterol(TC), triglyceride(TG), low density lipoprotein(LDL-C), high density lipoprotein cholesterol(HDL-C), glycated hemoglobin A1 c(HbA1 c), and performed oral glucose tolerance test and insulin release test before and after treatment. Homeostasis model insulin resistance index(HOMA-IR) was applied to assess the status of insulin resistance, 30 min net increment of insulin/30 min net increment of glucose(ΔI30/ΔG30) were used to evaluate the basic function of islet β cells. Results Compared with those before treatment, FPG,PPG,HbAlc and HOMA-IR were significantly lower after treatment in the two groups(P<0.05), while 30 min FINS and ΔI30/ΔG30 were significantly higher after treatment in the two groups(P<0.05). There were no significantly differences in FPG,PPG,HbAlc, HOMA-IR or ΔI30/ΔG30 after treatment in the control group compared with those of the observation group(P>0.05). After treatment, the serum levels of TC,TG and LDL-C in the control group and the observation group were decreased significantly(P<0.05). The LDL-C level in the observation group after treatment was lower than that in the control group after treatment(P<0.05). The gastrointestinal adverse reactions in the observation group were significantly lower than those in the control group(P<0.05). Conclusion Qihuang Jiangtang Capsule could effectively reduce the level of plasma glucose, serum lipid levels and insulin resistance and improve the function of islet in

关 键 词：初发2型糖尿病 杞黄降糖胶囊 胰岛功能 临床疗效 

分 类 号：R259.871[医药卫生—中西医结合]