Cascade N-Alkylation/Hemiacetalization for Facile Construction of the Spiroketal Skeleton of Acortatarin Alkaloids with Therapeutic Potentiality in Diabetic Nephropathy  

作　　者：Pei Cao Zhen-Jie Li Wen-Wu Sun Shashwat Malhotra Yuan-Liang Ma Bin Wu Virinder S.Parmar 

机构地区：[1]State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201,People’s Republic of China [2]University of Chinese Academy of Sciences,Beijing 100049,People’s Republic of China [3]Bioorganic Laboratory,Department of Chemistry,University of Delhi,Delhi 110007,India [4]Institute of Chemistry and Biochemistry,Freie Universita¨t Berlin,Takustrasse 3,14195 Berlin,Germany

出　　处：《Natural Products and Bioprospecting》2015年第1期37-45,共9页应用天然产物（英文）

基　　金：the“Hundred Talents Project”of Chinese Academy of Science and“High-end Science and Technology Talents Program”’of Yunnan Province(2011HA008)。

摘　　要：The concise building of the spiroketal core of acortatarin-type alkaloids as potential therapeutic agents in diabetic nephropathy was established in four steps,through a tandem N-alkylation/hemiacetalization between pyrrole units and the corresponding halo alcohols generated by convenient halomethylation of chiral lactones from natural aldoses.

关 键 词：Acortatarin alkaloids Diabetic nephropathy N-alkylation/hemiacetalization Halomethylation Chiral lactones 

分 类 号：O62[理学—有机化学]