Cycloartane Glycosides from the Roots of Cimicifuga foetida with Wnt Signaling Pathway Inhibitory Activity  

作　　者：Di-Fan Zhu Guo-Lei Zhu Ling-Mei Kong Ni-Man Bao Lin Zhou Yin Nian Ming-Hua Qiu 

机构地区：[1]State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201,China

出　　处：《Natural Products and Bioprospecting》2015年第2期61-67,共7页应用天然产物（英文）

基　　金：Program for National Natural Science Foundation of China(Nos.U1132604 and 81302670);The Major Deployment Program of the CAS(No.KSZDEW-Z-004-01);Foundation of State Key Laboratory of Phytochemistry and Plant Resources in West China(P2008-ZZ05).

摘　　要：Four new 9,19-cycloartane triterpenoids,cimilactone E(1),cimilactone F(2),20-O-(E)-butenoyl-23-epi-26-deoxyactein(3),and 20,12b-O-diacetylcimiracemonol-3-O-b-D-xylopyranoside(4),together with four known constituents(5–8)were isolated from the roots of Cimicifuga foetida.The new structures were elucidated by extensive spectroscopic analysis.In addition,compounds 7 and 8 showed significant Wnt signaling pathway inhibitory activity,with IC50 values of 3.33 and 13.34 lM,respectively,using the luciferase reporter gene assay.

关 键 词：Cimicifuga foetida 9 19-Cycloartane triterpenoids Cimilactone-type Wnt signal pathway Luciferase activity 

分 类 号：O63[理学—高分子化学]