A Viscidane Diterpene and Polyacetylenes from Cultures of Hypsizygus marmoreus  

作　　者：Ling Zhang Zheng-Hui Li Ze-Jun Dong Yan Li Ji-Kai Liu 

机构地区：[1]State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650204,China

出　　处：《Natural Products and Bioprospecting》2015年第2期99-103,共5页应用天然产物（英文）

基　　金：the National Natural Sciences Foundation of China(21302194).

摘　　要：Investigation on the cultures of Hypsizygus marmoreus resulted in the isolation of a new viscidane diterpene,8-oxoviscida-3,11(18)-diene-13,14,15,19-tetraol(1)and two new polyacetylenes,(E)-10-(1,1-dimethyl-2-propenyloxy)-2-decene-4,6,8-triyn-1-ol(2)and 10-(1,1-dimethyl-2-propenyloxy)deca-4,6,8-triyn-1-ol(3),together with two known polyacetylenes,(E)-2-decen-4,6,8-triyn-1-ol(4)and 4,6,8-decatriyn-1-ol(5).Their structures were elucidated on the basis of extensive spectroscopic studies.Compound 1 is the first finding of viscidane diterpene in mushrooms.Compounds 1,3 and 5 were tested for cytotoxicity against human tumor cell lines HL-60,SMMC-7721,A-549,MCF-7 and SW-480.None of the compounds showed cytotoxic activity(IC50[40 lM).

关 键 词：Hypsizygus marmoreus Viscidane diterpene POLYACETYLENES 

分 类 号：O62[理学—有机化学]