(±)-Evodiakine,A Pair of Rearranged Rutaecarpine-Type Alkaloids From Evodia rutaecarpa  

作　　者：Yan-Hong Li Yu Zhang Li-Yan Peng Xiao-Nian Li Qin-Shi Zhao Rong-Tao Li Xing-De Wu 

机构地区：[1]State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201,People’s Republic of China

出　　处：《Natural Products and Bioprospecting》2016年第6期291-296,共6页应用天然产物（英文）

基　　金：the NSFC-Joint Foundation of Yunnan Province(No.U1502223);the National Natural Science Foundation of China(No.21402212);the Science and Technology Program of Yunnan province(No.2015FB173);the CAS“Light of West China”Program and Youth Innovation Promotion Association CAS(X.-D.Wu).

摘　　要：(±)-Evodiakine(1a and 1b),a pair of rearranged rutaecarpine-type alkaloids with an unprecedented 6/5/5/7/6 ring system,were isolated from the nearly ripe fruits of Evodia rutaecarpa.Separation of the enantiomers have been achieved by chiral HPLC column.The structures of(±)-evodiakine were unambiguously elucidated by 1D and 2D NMR spectra,mass spectrometry,and single-crystal X-ray diffraction.Their absolute configurations were determined by comparison of experimental and calculated electronic circular dichroism spectra.A hypothetical biogenetic pathway for(±)-evodiakine was also proposed.Compounds 1a,1b,and the racemate(1)were tested for their cytotoxic and anti-inflammatory activities.

关 键 词：Evodia rutaecarpa (±)-Evodiakine Rutaecarpine-type alkaloids 

分 类 号：O62[理学—有机化学]