Isoprenylated Flavonoids with PTP1B Inhibition from Macaranga denticulata  

作　　者：Lai-Bin Zhang Chun Lei Li-Xin Gao Jing-Ya Li Jia Li Ai-Jun Hou 

机构地区：[1]Department of Pharmacognosy,School of Pharmacy,Fudan University,826 Zhang Heng Road,Shanghai 201203,People’s Republic of China [2]Department of Chinese Medicine,School of Pharmacy,Xinxiang Medical University,601 Jin Sui Road,Xinxiang 453003,People’s Republic of China

出　　处：《Natural Products and Bioprospecting》2016年第1期25-30,共6页应用天然产物（英文）

基　　金：Financial support from the National Natural Science Foundation of China(Nos.81222045,21372049);the Specialized Research Fund for the Doctoral Program of Higher Education of China(20130071120104);the Shu Guang Project(No.12SG02)from Shanghai Municipal Education Commission and Shanghai Education Development Foundation is gratefully acknowledged.

摘　　要：Three new C-methylated and isoprenylated chalcone derivatives,dentichalcones A–C(1–3),together with six known compounds(4–9),were isolated from the twigs and leaves of Macaranga denticulata.Their structures were elucidated by spectroscopic analysis,including 1D,2D NMR,and MS data.The known compounds,(2E)-1-(5,7-dihydroxy-2,2,6-trimethyl-2H-benzopyran-8-yl)-3-(4-methoxyphenyl)-2-propen-1-one(4),(2E)-1-(5,7-dihydroxy-2,2-dimethyl-2H-benzopyran-8-yl)-3-phenyl-2-propen-1-one(5),laxichalcone(6),macarangin(7),bonanniol A(8),and bonannione A(9),showed inhibitory activities against protein tyrosine phosphatase 1B(PTP1B)in vitro.Graphical Abstract Three new C-methylated and isoprenylated chalcone derivatives,dentichalcones A–C(1–3),together with six known compounds,were isolated from the twigs and leaves of Macaranga denticulata.Some compounds showed inhibitory activities against PTP1B in vitro.

关 键 词：Macaranga denticulata EUPHORBIACEAE Isoprenylated flavonoids Dentichalcones A-C Protein tyrosine phosphatase 1B 

分 类 号：O62[理学—有机化学]