The Use of a Combination of RDC and Chiroptical Spectroscopy for Determination of the Absolute Configuration of Fusariumin A from the Fungus Fusarium sp.  

作　　者：Liang-Yan Liu Han Sun Christian Griesinger Ji-Kai Liu 

机构地区：[1]College of Agronomy and Biotechnology,Yunnan Agricultural University,Kunming 650201,China [2]Department of NMR-based Structural Biology,Max-Planck-Institute of Biophysical Chemistry,Am Fassberg 11,37077 [3]Leibniz-Institut für Molekulare Pharmakologie,13125 Berlin,Germany [4]School of Pharmaceutical Sciences,South-Central University for Nationalities,Wuhan 430074,China

出　　处：《Natural Products and Bioprospecting》2016年第1期41-48,共8页应用天然产物（英文）

基　　金：Support by the National Natural Science Foundation of China(U1132607)to J.K.L.;the DFG(Forschergruppe FOR 934)to C.G;as well as the Chinese/German foundation(GZ1104)to H.S.and C.G.is acknowledged.

摘　　要：A new alkylpyrrole derivative,fusariumin A(1),was isolated from the culture broth of the fungus Fusarium sp.The absolute configuration of fuasiumin A has been established as(2'R,3'R)using a combination of RDC(residual dipolar coupling)-based NMR and DFT-supported chiroptical spectroscopy.It is worth to note that in this study without the aid of the RDC analysis,an unambiguous determination of configuration and conformation was not feasible due to the excessive conformational possibilities of this open-chain compound.

关 键 词：NMR Residual dipolar coupling Relative configuration Absolute configuration Chiroptics 

分 类 号：O62[理学—有机化学]