Phytochemical Analysis and Antifungal Activity of Extracts from Leaves and Fruit Residues of Brazilian Savanna Plants Aiming Its Use as Safe Fungicides  

作　　者：Caroline Alves Breda Alessandra Marcon Gasperini Vera Lucia Garcia Karin Maia Monteiro Giovana Anceski Bataglion Marcos Nogueira Eberlin Marta Cristina Teixeira Duarte 

机构地区：[1]School of Food Engineering,State University of Campinas,UNICAMP,Monteiro Lobato Street,80,BaraōGeraldo,Campinas,SaōPaulo 13083-862,Brazil [2]Microbiology Division of Research Center for Chemistry,Biology and Agriculture–CPQBA,University of Campinas,UNICAMP,Alexandre Cazelatto Street,999,Betel,Paulı´nia,SaöPaulo 13148-218,Brazil [3]Organic Chemistry and Pharmaceutical Division of Research Center for Chemistry,Biology and Agriculture–CPQBA,University of Campinas,UNICAMP,Alexandre Cazelatto Street,999,Betel,Paulínia,SaöPaulo 13148-218,Brazil [4]Pharmacology and Toxicology Division of Research Center for Chemistry,Biology and Agriculture–CPQBA,University of Campinas,UNICAMP,Alexandre Cazelatto Street,999,Betel,Paulínia,SaöPaulo 13148-218,Brazil [5]ThoMSon Mass Spectrometry Laboratory,Institute of Chemistry,State University of Campinas,UNICAMP,Campinas,SaōPaulo 13084-971,Brazil

出　　处：《Natural Products and Bioprospecting》2016年第4期195-204,共10页应用天然产物（英文）

基　　金：We are grateful to SaōPaulo Research Foundation for the financial support of this research and for the fellowships awarded to C.A.B.(FAPESP No.2011/19057-7);G.A.B.(FAPESP No.2012/21395-0);to Study Group of Cerrado Agroindustrial Processes(GEPPAC)of the Federal University of Grande Dourados to provide laboratories for plant material processing step.

摘　　要：The increasing demand for safe food without preservatives or pesticides residues has encouraged several studies on natural products with antifungal activity and low toxicity.In this study,ethanolic extracts from leaves and fruit residues(peel and seeds)of three Brazilian savanna species(Acrocomia aculeata,Campomanesia adamantium and Caryocar brasiliense)were evaluated against phytopathogenic fungi.Additionally,the most active extract was chemically characterized by ESI-MS and its oral acute toxicity was evaluated.Extracts from C.brasiliense(pequi)peel and leaves were active against Alternaria alternata,Alternaria solani and Venturia pirina with minimal inhibitory concentrations between 350 and 1000 lg/mL.When incorporated in solid media,these extracts extended the lag phase of A.alternata and A.solani and reduced the growth rate of A.solani.Pequi peel extract showed better antifungal activity and their ESI-MS analysis revealed the presence of substances widely reported as antifungal such as gallic acid,quinic acid,ellagic acid,glucogalin and corilagin.The oral acute toxicity was relatively low,being considered safe for use as a potential natural fungicide.

关 键 词：Brazilian savanna fruits RESIDUES Natural fungicides PHYTOPATHOGENS 

分 类 号：R28[医药卫生—中药学]