Spiralosides A–C, Three New C_(27)-Steroidal Glycoalkaloids from the Fruits of Solanum spirale  

作　　者：Dan Li Yun-Li Zhao Xu-Jie Qin Lu Liu Xing-Wei Yang Ying-Ying Chen Bei Wang Xin Wei Ya-Ping Liu Xiao-Dong Luo 

机构地区：[1]State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201,China [2]University of Chinese Academy of Sciences,Beijing 100039,China

出　　处：《Natural Products and Bioprospecting》2016年第4期225-231,共7页应用天然产物（英文）

基　　金：The authors are grateful to the Natural Science Foundation of China(81225024);to the analytical group of the Laboratory of Phytochemistry,Kunming Institute of Botany for spectral measurements.

摘　　要：Three new C_(27)-steroidal glycoalkaloids,spiralosides A–C(1–3),were obtained from the total alkaloids of Solanum spirale by chromatographic methods.On the basis of spectroscopic evidence,spiralosides A–C were elucidated as(22R,25S)-22,26-epiminocholest-5-ene-3β,16a-diol-N-acetyl-3-O-α-L-rhamnopyranosyl-(1→4)-β-D-glucopyranosyl(1),(22R,25S)-22,26-epiminocholest-5-ene-3β,16α-diol-N-acetyl-3-O-β-D-glucopyranosyl(2),(22R,25S)-22,26-epiminocholest-3β,16α-diol-N-acetyl-3-O-β-D-glucopyranosyl(3),respectively.The total alkaloids of S.spirale have been screened for their antitussive and expectorant effects in intact animal model.

关 键 词：SOLANACEAE Solanum spirale Spiralosides A-C 

分 类 号：O62[理学—有机化学]