Clerodane Diterpenoids with Anti-hyperglycemic Activity from Tinospora crispa  

作　　者：Yuan Gao Yan-Fen Niu Fei Wang Ping Hai Fang Wang Yin-Dong Fang Wen-Yong Xiong Ji-Kai Liu 

机构地区：[1]State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201,Yunnan,People’s Republic of China [2]Department of Chemical Engineering,Yibin University,Yibin 644000,People’s Republic of China [3]BioBioPha Co.,Ltd,Kunming 650201,People’s Republic of China [4]Graduate University of Chinese Academy of Sciences,Beijing 100049,People’s Republic of China [5]Yunnan University,Kunming 650091,People’s Republic of China [6]School of Pharmaceutical Sciences,South-Central University for Nationalities,Wuhan 430074,China

出　　处：《Natural Products and Bioprospecting》2016年第5期247-255,共9页应用天然产物（英文）

基　　金：This work was financially supported by“Largescale Compound Library”Project of National Development Reform Commission of China,National Natural Science Foundation of China(81561148013 to J.L.);the Chinese Academy of Sciences(292013312 D11004 to W.X.);Yibin University(2015QD06 to Y.G.);Sciences Foundation of Yunnan Province(39Y33H521261 to W.X.).

摘　　要：Four new clerodane diterpenoids,tinosporols A–C(2–4)and tinosporoside A(5),together with six known analogues were isolated from the vines of Tinospora crispa.Their structures were established by extensive spectroscopic analysis.The relative configuration at C-12 in the known diterpenoid borapetoside E(1),the major component of the plant,was firstly established with the aid of molecular model.Compound 1 significantly reduced serum glucose levels at dosedependent manners in alloxan-induced hyperglycemic mice and db/db type 2 diabetic mice.

关 键 词：ANTI-HYPERGLYCEMIA 

分 类 号：O62[理学—有机化学]