力竭运动过程中大鼠皮层–基底神经节通路α/β同步振荡的起源和传递路径  

Origin and Transmission Pathways of Alpha and Beta Synchronous Oscillatory Activity in the Cortical-Basal Ganglia Pathway of Rats Undergoing Exhaustive Exercise

作　　者：黄浩洁 侯莉娟[1] 刘晓莉[1] 乔德才[1] Huang Haojie;Hou Lijuan;Liu Xiaoli;Qiao Decai(College of Physical Education and Sports,Beijing Normal University,Beijing 100875,China;College of Physical Education,Xiamen University,Xiamen 361005,China)

机构地区：[1]北京师范大学体育与运动学院,北京100875 [2]厦门大学体育教学部,厦门361005

出　　处：《中国运动医学杂志》2021年第4期276-286,共11页Chinese Journal of Sports Medicine

基　　金：国家自然科学基金项目(31971095);中央高校基本科研业务费项目(20720211351)。

摘　　要：目的:探讨一次力竭运动过程中皮层–基底神经节通路振荡电活动变化特征、同步振荡电活动的起源和传递路径以及运动疲劳产生的振荡电活动中枢调控机制。方法:以健康4周龄雄性Wistar大鼠为研究对象,采用在体多通道神经电信号记录技术,对一次性力竭运动过程中大鼠皮层(M1)和基底神经节(Str、GPe、SNr和STN)的局部场电位(local field potentials,LFPs)进行同步记录;根据大鼠跑台运动特征把运动力竭过程划分为安静期、自主运动期、运动疲劳初期、力竭期(运动疲劳后期)和恢复初期5个阶段;采用功率谱密度(power spectral density,PSD)探究力竭运动过程中不同阶段各核团同步振荡电活动的变化特征;采用Granger因果分析方法进一步探究同步振荡电活动的起源和传递路径。结果:1)与安静期相比,自主运动期、运动疲劳初期和力竭期LFPs平均振幅值显著升高(P<0.05);2)与安静期相比,大鼠自主运动时,皮层和基底神经节在δ/θ频段(1-8 Hz)PSD值均显著升高(P<0.05);3)与自主运动期相比,运动疲劳初期和力竭期α/β频段(12-18 Hz)和β频段(16-24 Hz)PSD值均显著升高(P<0.05);4)大鼠在自主运动期Granger因果系数主要是在以M1和Str为起始向其他核团传递的方向上在δ/θ频段显著升高(P<0.05),而在运动疲劳初期和力竭期,则是以STN(STN→M1、STN→GPe和STN→SNr)和GPe(GPe→STN、GPe→Str和GPe→SNr)为起始向其他核团传递的方向上在α/β频段显著升高(P<0.05)。结论:一次力竭运动过程中,皮层–基底神经节通路广泛存在的δ/θ振荡电活动同步化增强具有促运动效应,促进自主运动,δ/θ振荡的起源和传递路径可能是以M1为起始向基底神经节各核团传递或M1先传递给纹状体然后再传递给基底神经节其他核团;而皮层–基底神经节通路广泛出现的α/β振荡电活动同步化增强则具有抑制运动效应,参与调控运动疲劳,α/β同步振荡Objective To explore the characteristics of oscillatory electrical activity in the corticalbasal ganglia pathway,as well as the origin and transmission path of synchronous oscillatory electrical activity and the central regulation mechanism of oscillatory electrical activity for rats undergoing exercise fatigue. Methods The local field potentials(LFPs) of the cortical-basal ganglia pathway(M1,Str,GPe, SNr and STN) were recorded using the vivo neural signal multichannel recording system for healthy 4-week male Wistar rats undergoing an acute exhaustive exercise. Their treadmill motion was divided into a resting period,an autonomic exercise period,initial fatigue period,exhaustion period(latersports fatigue period) and early recovery period. The characteristics of oscillatory activity of cortical-basal ganglia at different frequency bands at different periods was analyzed using the power spectral density(PSD),while the origin and transmission path of synchronous oscillations were explored using the granger causality analysis. Results The average amplitude of LFPs of the autonomic exercise,initial fatigue and exhaustion periods increased significantly compared with the resting period(P<0.05).The average PSD of cortical-basal ganglia in five periods at δ/θ bands(1~8 Hz) increased significantly compared with that of the resting period(P<0.05). Compared with the autonomic exercise period,the average PSD of the cortical-basal ganglia in the initial fatigue and exhaustion periods increased significantly(P<0.05) in α/β band(12~18 Hz) and β band(16~24 Hz)respectively. The granger causality coefficient in the autonomic exercise period increased significantly at δ/θ band in the direction of transmission from M1 and Str to other nuclei(P<0.05). However,in the initial fatigue and exhaustion period,the coefficient increased significantly at α/β band(8~30 Hz) in the direction of transmission from STN(STN→M1,STN→GPe and STN→SNr) and GPe(GPe→STN,GPe→Str and GPe→SNr) to other nuclei(P<0.05). Conclusion During e

关 键 词：运动疲劳 皮层–基底神经节 振荡电活动 局部场电位 

分 类 号：G804.7[文化科学—运动人体科学]