Structurally Diverse Sesquiterpenoids with Anti-neuroinflammatory Activity from the Endolichenic Fungus Cryptomarasmius aucubae  

作　　者：Yi-Jie Zhai Jian-Nan Li Yu-Qi Gao Lin-Lin Gao Da-Cheng Wang Wen-Bo Han Jin-Ming Gao 

机构地区：[1]Shaanxi Key Laboratory of Natural Products and Chemical Biology,College of Chemistry and Pharmacy,Northwest A&F University,Yangling,Shaanxi 712100,People’s Republic of China

出　　处：《Natural Products and Bioprospecting》2021年第3期325-332,共8页应用天然产物（英文）

基　　金：This work was financed by the National Natural Science Foundation of China(Grant Nos.21702169,22077102).

摘　　要：Two new sterpurane sesquiterpenoids named sterpurol D(1)and sterpurol E(2),and one skeletally new sesquiterpene,cryptomaraone(3),bearing a 5,6-fused bicyclic ring system,along with five known ones,sterpurol A(4),sterpurol B(5),paneolilludinic Acid(6),murolane-2α,9β-diol-3-ene(7)and(-)-10,11-dihydroxyfarnesol(8)were isolated from an endolichenic fungus Cryptomarasmius aucubae.The structures of the new compounds were elucidated by analysis of NMR spectroscopic spectra and HRESIMS data.The absolute configurations of 1 and 2 were established by spectroscopic data analysis and comparison of specific optical rotation,as well as the biosynthetic consideration.Additionally,compounds 1,2,4-6,and 8 showed significant nitric oxide(NO)production inhibition in Lipopolysaccharide(LPS)-induced BV-2 microglial cells with the IC50 values ranging from 9.06 to 14.81μM.

关 键 词：Endolichenic fungus Cryptomarasmius aucubae SESQUITERPENES Anti-neuroinflammatory activity 

分 类 号：R318[医药卫生—生物医学工程]