Five New Guanacastane-Type Diterpenes from Cultures of the Fungus Psathyrella candolleana  

作　　者：Xia Yin Tao Feng Zheng-Hui Li Ying Leng Ji-Kai Liu 

机构地区：[1]State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201,People’s Republic of China [2]University of Chinese Academy of Sciences,Beijing 100049,People’s Republic of China [3]Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,People’s Republic of China

出　　处：《Natural Products and Bioprospecting》2014年第3期149-155,共7页应用天然产物（英文）

基　　金：the National Natural Sciences Foundation of China(U1132607,81373289).

摘　　要：Five new guanacastane-type diterpenes,named guanacastepenes P–T(1–5),were isolated from cultures of the fungus Psathyrella candolleana.Their structures were elucidated on the basis of extensive spectroscopic methods.All of the compounds were tested for their 11b-hydroxysteroid dehydrogenase(11b-HSD1)inhibitory activity.Compound 3 exhibited inhibitory activity against both human and mouse isozymes of 11b-HSD1 with IC50 values of 6.2 and 13.9 lM,respectively.

关 键 词：Psathyrella candolleana Psathyrellaceae diterpenes Guanacastepenes P-T 11b-HSD1 

分 类 号：O62[理学—有机化学]