Chemical Constituents from Mentha haplocalyx Briq.(Mentha canadensis L.)and Theirα‑Glucosidase Inhibitory Activities  

作　　者：Xiao-Feng He Chang-An Geng Xiao-Yan Huang Yun-Bao Ma Xue-Mei Zhang Ji-Jun Chen 

机构地区：[1]State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201,People’s Republic of China [2]Yunnan Key Laboratory of Natural Medicinal Chemistry,Kunming 650201,China [3]University of Chinese Academy of Sciences,Beijing 100049,China

出　　处：《Natural Products and Bioprospecting》2019年第3期223-229,共7页应用天然产物（英文）

基　　金：supported by the CAS Hundred Talents Program,the Youth Innovation Promotion Association of the Chinese Academy of Sciences(CN),and Southeast Asia Biodiversity Research Institute,CAS(2017CASSEABRIQG003).

摘　　要：Mentha haplocalyx(Mentha canadensis)is widely used as a medicinal plant in traditional Chinese medicine,and the extracts of its aerial parts are found to signifcantly inhibit the activity ofα-glucosidase with an IC_(50) value of 21.0μg/mL.Bioactivity-guided isolation of the extracts aforded two new compounds(1 and 2),together with 23 known ones(3-25).Their structures were established by extensive spectroscopic analyses(1D and 2D NMR,MS,IR and UV).Compounds 1-17 and 21-25 were evaluated for theirα-glucosidase inhibitory activities.Compound 11 was the most active ones with an IC_(50) values of 83.4μM.These results verify theα-glucosidase inhibitory activity of M.haplocalyx(M.canadensis)and specify its active compounds for the frst time.

关 键 词：Mentha haplocalyx Briq.(Mentha canadensis L.) Lamiaceae α-Glucosidase inhibitor 

分 类 号：R28[医药卫生—中药学]