Four New Phloroglucinol-Terpene Adducts from the Leaves of Myrciaria cauliflora  

作　　者：Ming Chen Jia-Qing Cao Wen-Jing Wang Ni-Ping Li Yan Wu Lei Wang Wen-Cai Ye 

机构地区：[1]Institute of Traditional Chinese Medicine&Natural Products,College of Pharmacy,Jinan University,Guangzhou 510632,People’s Republic of China [2]Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research,Jinan University,Guangzhou 510632,People’s Republic of China

出　　处：《Natural Products and Bioprospecting》2021年第1期111-118,共8页应用天然产物（英文）

基　　金：supported by the National Key R&D Program of China(No.2017YFC1703800);the Program for the National Natural Science Foundation of China(Nos.81822042,81630095);the Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(2017BT01Y036);Key-Area Research and Development Program of Guangdong Province(2020B1111110004);the High-performance Computing Platform of Jinan University.

摘　　要：Myrcauones A-D(1-4),four new phloroglucinol-terpene adducts were isolated from the leaves of Myrciaria cauliflora.Their structures with absolute configurations were elucidated by combination of spectroscopic analysis,single crystal X-ray diffraction,and electronic circular dichroism(ECD)calculations.Compound 1 was a rearranged isobutylphloroglucinol-pinene adduct featuring an unusual 2,3,4,4a,10,11-hexahydro-1H-3,11a-methanodibenzo[b,f]oxepin backbone.Compound 4 showed moderate antibacterial activity against Gram-positive bacteria including multiresistant strains.

关 键 词：Myrciaria cauliflora Phloroglucinol-terpene adducts Antibacterial activity 

分 类 号：O62[理学—有机化学]