Anti-microbial Effects In Vitro and In Vivo of Alstonia scholaris  

作　　者：Yun-Li Zhao Zhong-Ping Gou Jian-Hua Shang Wan-Yi Li Yu Kuang Ming-Yuan Li Xiao-Dong Luo 

机构地区：[1]State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201,People’s Republic of China [2]Key Laboratory of Medicinal Chemistry for Natural Resource,Ministry of Education,Yunnan Provincial Center for Research&Development of Natural Products,School of Chemical Science and Technology,Yunnan University,Kunming 650091,P.R.China [3]Institute of Drug Clinical Trials,West China Hospital,Sichuan University,Chengdu 610041,China [4]West China School of Basic Medical Sciences&Forensic Medicine,Sichuan University,Chengdu 610041,China

出　　处：《Natural Products and Bioprospecting》2021年第1期127-135,共9页应用天然产物（英文）

基　　金：The authors are grateful to the general program of applied basic research of Yunnan province(2019FB116);the National Key Research and Development Program of China(2017YFC1704007)for partly financial support.

摘　　要：Alstonia scholaris could be used as a traditional medicinal plant in China for the treatment of acute respiratory,which might be caused by respiratory tract infections.The investigation tested the anti-infective effects of total alkaloids extract(TA)from leaves of A.scholaris,and as a result,TA inhibited herpes simplex virus type 1(HSV-1),respiratory syncytial virus(RSV)and influenza A virus(H1N1)in vitro respectively.In addition,the survival days of mice were prolonged,and the lung weights and mortality of mice were decreased significantly,after oral administrated TA in H1N1 and beta-hemolytic streptococcus infectious models in vivo respectively.The finding supported partly the traditional usage of A.scholaris in the treatment of respiratory infections.

关 键 词：Alstonia scholaris Total alkaloids Acute respiratory infections ANTI-VIRUS ANTI-BACTERIA 

分 类 号：R285[医药卫生—中药学]