Cucurbitane-Type Triterpene Glycosides from Momordica charantia and Their α-Glucosidase Inhibitory Activities  

作　　者：Ya Gao Jian-Chao Chen Xing-Rong Peng Zhong-Rong Li Hai-Guo Su Ming-Hua Qiu 

机构地区：[1]State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201,People’s Republic of China [2]University of the Chinese Academy of Sciences,Beijing 100049,People’s Republic of China [3]Yunnan Key Laboratory of Natural Medicinal Chemistry,Chinese Academy of Sciences,Kunming 650201,People’s Republic of China

出　　处：《Natural Products and Bioprospecting》2020年第3期153-161,共9页应用天然产物（英文）

基　　金：supported by a program of the National Natural Science Foundation of China(Nos.31872675 and 81373288);the cooperation program between Chinese Academy of Sciences and Guangdong Province(2013B09110011).

摘　　要：Ten cucurbitane-type triterpene glycosides,including five new compounds named charantosides H(1),J(2),K(3),momor-characoside A(4),goyaglycoside-l(5),and five known compounds(6-10),were isolated from the EtOAc extract of Momor-dica charantia fruits.The chemical structures of these compounds were identified by 1D and 2D NMR and HRESIMS spectroscopic analyses.Configurations of new compounds were determined by ROESY correlations and comparison of their 13C NMR data with literature reported values.All compounds were evaluated for their inhibition againstα-glucosidase,in which compounds 2,5,7,8,9 showed moderate inhibitory activities with IC50 values ranging from 28.40 to 63.26μM comparing with the positive control(acarbose,IC5087.65±6.51μM).

关 键 词：Momordica charantia Cucurbitane-type triterpene glycosides α-Glucosidase inhibitory activity 

分 类 号：R285[医药卫生—中药学]