安宫牛黄丸联合力奥来素治疗神经重症间脑发作综合征效果观察  

Observation on Effect of Angong Niuhuang Pill(安宫牛黄丸) Combined with Lioresal on Neurosevere Diencephalic Attack Syndrome

作　　者：张巧萍[1] 木冬妹[1] 陈露露 陈晓青[2] ZHANG Qiaoping;MU Dongmei;CHEN Lulu;CHEN Xiaoqing(The Second Affiliated Hospital of Wenzhou Medical University,Wenzhou 325027,Zhejiang,China;First Affiliated Hospital of Wenzhou Medical University,Wenzhou 325015,Zhejiang,China)

机构地区：[1]温州医科大学附属第二医院,浙江温州325027 [2]温州医科大学附属第一医院,浙江温州325015

出　　处：《中华中医药学刊》2021年第5期41-43,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：国家中医药管理局中医药行业科研项目(201608996);浙江省卫生与计划生育委员会基金(2018KY515);温州市科技局项目(Y20190357)。

摘　　要：目的观察安宫牛黄丸联合力奥来素对神经重症间脑发作综合征效果。方法选取在医院ICU住院的神经危重伴间脑发作综合征患者30例,分为两组。两组患者均积极治疗原发病,对照组给予β受体阻滞剂联合多巴胺受体激动剂治疗,观察组在对照组基础上给予安宫牛黄丸联合力奥来素治疗,分析两组患者治疗后的效果。结果观察组ICU住院时间(42.92±9.26)d、总住院时间(50.10±10.63)d、机械通气时间(11.02±2.85)d短于对照组(P<0.05)。两组治疗前格拉斯哥昏迷指数(GCS)评分组间比较,差异不具有统计学意义(P>0.05)。观察组治疗后GCS评分(9.10±1.43)分高于对照组(P<0.05)。所有患者均获得随访,6个月后观察组中度残疾3例,重度残疾7例,植物生存4例,死亡1例,对照组中度残疾1例,重度残疾6例,植物生存5例,死亡3例。观察组整体预后优于对照组,但与对照组比较,差异不具有统计学意义(P>0.05)。结论安宫牛黄丸联合力奥来素用于神经重症间脑发作综合征可缩短住院时间,改善GCS评分,值得临床应用推荐。Objective To observe the effect of Angong Niuhuang Pill(安宫牛黄丸) combined with Lioresal on severe diencephalic attack syndrome. Methods Thirty patients with neurological crisis complicated with diencephalic attack syndrome hospitalized in ICU were divided into two groups. All patients were actively treated for primary diseases. The control group was given a combination of the androgen receptor blocker and the dopamine receptor agonist, and the observation group was given the combination of Angong Niuhuang Pill and Lioresal on the basis of the control group, and the effect of the two groups was analyzed. Results In the observation group, the hospitalization time of ICU was(42.92±9.26) days, and the total hospitalization time was(50.10±10.63) days. The time of mechanical ventilation(11.02±2.85) d was shorter than that of the control group(P<0.05). There was no significant difference in the Glasgow coma score(GCS) between the two groups before treatment. After treatment, the GCS score in the observation group[(9.10±1.43) points] was higher than that in the control group(P<0.05). All the patients were followed up. Six months later, there were 3 cases of moderate disability, 7 cases of severe disability, 4 cases of plant survival and 1 death in the observation group. In the control group, there was 1 case of moderate disability, 6 cases of severe disability, 5 cases of plant survival and 3 cases of death. The overall prognosis of the observation group was better than that of the control group, but there was no significant difference between the observation group and the control group(P>0.05). Conclusion Angong Niuhuang Pill combined with Lioresal can shorten the hospitalization time and improve GCS score in patients with severe diencephalic attack syndrome, which is worthy of recommendation for clinical application.

关 键 词：安宫牛黄丸 力奥来素 神经重症 间脑发作综合征 

分 类 号：R277.742.81[医药卫生—中医学]