雷公藤多苷不良反应及配伍减毒研究进展  

Research Progress on Adverse Reactions and Reducing Toxicity of Tripterygium Glycosides

作　　者：姜淼[1] 张海波 张霞[1] 丁樱[1,3] JIANG Miao;ZHANG Haibo;ZHANG Xia;DING Ying(First Affiliated Hospital of Henan University of Chinese Medicine,Henan Childrens Hospital of Integrated Traditional Chinese and Western Medicine,Zhengzhou 450004,Henan,China;Kyungpook National University,Gyeongsangbuk-do 37224,South Korea;Henan University of Chinese Medicine,Zhengzhou 450046,Henan,China)

机构地区：[1]河南中医药大学第一附属医院,河南省中西医结合儿童医院,河南郑州450004 [2]庆北大学,韩国庆上北道37224 [3]河南中医药大学,河南郑州450046

出　　处：《中华中医药学刊》2021年第5期64-66,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：国家“十二五”科技支撑计划(2013BAI02B07)。

摘　　要：雷公藤多苷是雷公藤的主要活性成分。雷公藤多苷具有较强的抗炎及免疫调节等作用,广泛用于炎症反应及自身免疫性疾病的治疗。雷公藤多苷治疗窗口较窄,不良反应发生率较高,主要涉及肝脏、肾脏、生殖内分泌系统等。临床常采用联合用药的方式,以达到减毒增效的目的。对近年来雷公藤多苷的不良反应及配伍减毒研究情况进行了系统的梳理和阐述,以期为临床合理应用提供参考。Tripterygium glycosides(TG) is the main active chemical constituents of Leigongteng(Tripterygium wilfordii Hook.F). TG exhibits anti-inflammatory and immune regulation effects, and is widely used in inflammatory response and autoimmune diseases. TG has a narrow therapeutic index and a high incidence of adverse reactions, mainly involving liver, kidney and reproductive endocrine system. Combination therapy has been used in order to achieve the purpose of reducing toxicity and increasing efficacy. This review summarized the adverse reactions and combination with drugs to reduce toxicity of TG in recent years in order to facilitate the rational application of TG.

关 键 词：雷公藤多苷 不良反应 减毒 

分 类 号：R285.5[医药卫生—中药学]