“气郁体质致轻度认知功能障碍”和“疏肝解郁法调体干预气郁质轻度认知功能障碍”的认知心理学研究可行性  

Discussion on Feasibility of Cognitive Psychology Research on "Qi-Stagnation Constitution Causing MCI" and "Soothing Liver-Qi Stagnation and Body Regulating Intervention on Qi-Stagnation Constitution MCI"

作　　者：秦中朋 詹向红[1] QIN Zhongpeng;ZHAN Xianghong(College of Basic Medicine,Henan University of Chinese medicine,Zhengzhou 450046,Henan,China)

机构地区：[1]河南中医药大学基础医学院,河南郑州450046

出　　处：《中华中医药学刊》2021年第5期133-136,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金(81873208,81473556,81173148);河南省重点研发与推广专项(182102310269);河南中医药大学研究生科研创新基金(2019KYCX014)。

摘　　要：轻度认知功能障碍(mild cognitive impairment, MCI)是介于正常脑老化与老年痴呆的过渡阶段,其进展成为痴呆的概率是正常中老年人的10倍,是预防和延缓进展为痴呆的关键期。随着当前经济社会的快速发展和生物—心理—社会医学模式的发展转变,负性情绪积累已被证实与MCI的发生发展关系密切。中医体质学说在缓衰益智方面具有独特优势,其中长期情志不畅、气机郁滞的气郁质人群往往性格内向不稳定、敏感多疑、忧郁脆弱而感知或遭受更多的负性情绪导致气机郁滞肝失疏泄,影响认知功能衰退而致MCI。近年来认知心理学技术ERPs、fMRI、眼动技术等被誉为是观察脑高级功能的窗口,前瞻记忆损伤是MCI的早期敏感指标,因此从前瞻记忆角度入手充分探讨以上3种技术结合神经心理学量表探索"气郁体质致MCI"的认知心理学研究可行性,并基于"体病相关""体质可调""调体干预"的"调体治未病理论"提出使用疏肝解郁方药逍遥丸以调体改善气郁体质状态进而"既病防变"纠正和延缓MCI向痴呆进展的可能性,以期为MCI的早期预防和临床干预提供参考和指导。Mild cognitive impairment(MCI) is a transitional stage between normal brain aging and Alzheimer’s disease. The probability of MCI progressing to dementia is 10 times higher than that of normal middle-aged people, and it is the key to preventing and delaying the progression to dementia. With the rapid development of economic society and the transformation of bio-psycho-social medical model, negative emotion accumulation has been proved to be closely related to the occurrence and development of MCI. The theory of traditional Chinese medicine constitution has a unique advantage in slowing down the decline and improving the intelligence.Among them, the group of Qi-stagnation constitution with long-term emotion is often introverted and unstable, sensitive and suspicious, and melancholic and fragile, and feel or suffer more negative emotions, which lead to Qi-stagnation constitution and liver dysfunction, and affect cognitive function decline, leading to MCI. In recent years, cognitive psychology techniques such as ERPs, fMRI and eye tracking are regarded as the window to observe the advanced functions of brain. Prospective memory impairment is an early sensitive index of MCI. Therefore, from the perspective of prospective memory, this study fully explored the feasibility of cognitive psychology of "Qi-stagnation constitution causing MCI" by combining the above three techniques with neuropsychological scale, and based on "constitutions related with diseases","regulating constitution and treating disease before treatment" and "regulating constitution", it is proposed to use Xiaoyao Pill(逍遥丸) to improve the state of Qi stagnation constitution and then "prevent disease and change" to correct and delay the progression of MCI to dementia, so as to provide reference and guidance for the early prevention and clinical intervention of MCI.

关 键 词：气郁体质 轻度认知功能障碍 前瞻记忆 疏肝解郁法 逍遥丸 事件相关电位技术 眼动技术 功能磁共振成像技术 

分 类 号：R277.749.16[医药卫生—中医学]