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作 者:陈权 徐颖扉[2] 陈培丰[2] CHEN Quan;XU Yingfei;CHEN Peifeng(The First Clinical Medical College of Zhejiang Chinese Medical University,Hangzhou 310053,Zhejiang,China;The First Affiliated Hospital of Zhejiang Chineses Medical University,Hangzhou 310006,Zhejiang,China)
机构地区:[1]浙江中医药大学第一临床医学院,浙江杭州310053 [2]浙江中医药大学附属第一医院,浙江杭州310006
出 处:《中华中医药学刊》2021年第5期255-258,共4页Chinese Archives of Traditional Chinese Medicine
基 金:浙江省中医药科技计划(2010ZA031)。
摘 要:目的建立大鼠异嗜高岭土模型,研究温胆汤治疗化疗所致迟发性呕吐(CINV)的疗效及对胃肠激素分泌的影响,对其作用机制进行初步探讨。方法30只大鼠先行适应性高岭土饲养,然后随机分为6组:对照组,模型组,昂丹司琼组,温胆汤低、中、高剂量组,每组5只,除对照组外,其余各组均腹腔注射顺铂以制造化疗所致的大鼠嗜高岭土模型,观察并记录造模后48 h内大鼠正常饲料及高岭土的耗用量;测定外周血血管活性肠肽(VIP)、表皮生长因子(EGF)、胃泌素(Gas)及大鼠胃窦组织P物质(SP)的表达。结果实验成功建立大鼠异嗜高岭土模型。在造模后48 h内,与模型组相比,温胆汤高、中剂量组大鼠的摄食量明显增加(P<0.05);温胆汤高、中剂量组大鼠对高岭土的耗用量明显减少(P<0.01);温胆汤高、中、低剂量组均能显著降低异嗜大鼠外周血中VIP(P<0.01)和Gas(P<0.05)的含量,均可促进异嗜大鼠外周血中EGF的表达(P<0.01);温胆汤高、中剂量组能显著减少异嗜大鼠胃窦组织SP免疫组化表达(P<0.01)。结论温胆汤对化疗所致迟发性呕吐有一定疗效,其作用机制与调节胃肠激素分泌,保护胃肠黏膜,促进胃排空并抑制胃窦组织SP的表达等有关。Objective To establish a rat model of heterophilic kaolin and study the effect of Wendan Decoction(温胆汤)on chemotherapy induced nausea and vomiting(CINV)and its effect on gastrointestinal hormone secretion and explore its mechanism.Methods Thirty rats were firstly fed with adaptive kaolin,and then randomly divided into 6 groups:control group,model group,ondansetron group,high,middle and low dosage groups of Wendan Decoction,5 rats in each group.Except the control group,the other groups were intraperitoneally injected cisplatin to make the heterophilic kaolin model induced by chemotherapy.The consumption of normal feed and kaolin was observed and recorded within 48 hours after making the model.The expressions of vasoactine intrestinal peptide(VIP),epidermal growth factor(EGF)and gastrin(Gas)in peripheral blood and substance P(SP)in gastric antrum of rats were measured.Results 1.The rat model of heterophilic kaolin was established successfully.Compared with the model group,the consumption of normal feed in high and middle dosage groups of Wendan Decoction increased significantly(P<0.05),while the consumption of kaolin decreased(P<0.01).All groups of Wendan Decoction could significantly reduce the contents of VIP(P<0.01)and Gas(P<0.05)and promote the expression of EGF in the peripheral blood of heterophilic rats(P<0.01).The high and middle dosage of Wendan Decoction could significantly reduce the SP immunohistochemical expression in gastric antrum tissue of heterophilic rats(P<0.01).Conclusion Wendan Decoction has a certain curative effect on CINV.Its mechanism was related to regulating the secretion of gastrointestinal hormones,protecting gastrointestinal mucosa,promoting gastric emptying and inhibiting the expression of SP in gastric antrum.
关 键 词:温胆汤 化疗所致迟发性呕吐(CINV) 胃肠激素 P物质
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