甘松中医药用药规律的数据挖掘  

Data mining of compatibility characteristics for Chinese medicinal prescriptions containing Nardostachyos Radix et Rhizoma

作　　者：饶瑶 李冉 王晓雯 薛变霞 李世伟 赵悦 张丽花 徐砚通[1,2] 吴红华 RAO Yao;LI Ran;WANG Xiao-wen;XUE Bian-xia;LI Shi-wei;ZHAO Yue;ZHANG Li-hua;XU Yan-tong;WU Hong-hua(State Key Laboratory of Component-based Chinese Medicine,Institute of Traditional Chinese Medicine,Tianjin University ofTraditional Chinese Medicine,Tianjin 301617,China;Beijing Research Institute of Chinese Medicine,Beijing University of Chinese Medicine,Beijing 100029,China)

机构地区：[1]天津中医药大学中医药研究院组分中药国家重点实验室,天津301617 [2]北京中医药大学北京中医药研究院,北京100029

出　　处：《中草药》2021年第11期3331-3343,共13页Chinese Traditional and Herbal Drugs

基　　金：天津市自然科学基金一般项目(8JCYBJC94600);国家自然科学基金青年基金项目(81603250);国家“重大新药创制”科技重大专项(2018ZX09735-002)。

摘　　要：目的从含甘松Nardostachyos Radix et Rhizoma的中医药处方和中药组合物专利中挖掘甘松的中医药用药规律,为甘松现代临床应用和开发提供依据。方法检索《中华医方》《中医方剂大辞典》《中国药典》2020年版等工具书及华柄数据、中医资源网、中国知网、万方等数据库中含甘松的中医药处方和中药组合物专利。运用Excel 2019、SPSS Modeler 18.0和SPSS Statistics 25软件,进行组成药物的频次统计、关联规则分析和聚类分析。结果含甘松的中医药处方最终纳入372首,涉及《中国药典》收载药物374种,与甘松组合用药频次最高的前10味药为白芷、香附、甘草、木香、川芎、细辛、山柰、丁香、当归和砂仁,功效分类以解表药为主,主治疾病以脾系病类最多,核心药物组合为木香分气丸加减方。含甘松的中药组合物专利最终纳入1533项,涉及《中国药典》收载药物565种,与甘松组合用药频次最高的前10味药为甘草、白芷、丁香、当归、茯苓、川芎、木香、肉桂、黄芪和陈皮,功效分类以补益药为主,主治疾病以脾系病类为首,比传统中医药处方发展了更多的药物组合。结论含甘松的中医药处方与中药组合物专利中药物组成均以解表药、补益药、理气药、活血药、温里药和清热药为主;甘松多与辛、苦、甘味,性温、寒、平,归脾、肝、胃、肺、心、肾经的药物配伍;常用于治疗脾系病类,皮肤病类,躯体痹、痿、瘤等病类,脑系病类和心系病类,与甘松国内外现代药理研究结果基本一致。Objective To explore the traditional Chinese medicine(TCM) medication pattern of Gansong(Nardostachyos Radix et Rhizoma) from TCM prescriptions and modern composition patents of TCM containing Nardostachyos Radix et Rhizoma and provide a basis for modern clinical application and development of Nardostachyos Radix et Rhizoma. Methods Data retrieval in reference books or online databases includes Chinese Medical Prescriptions,Chinese Dictionary of Medical Prescriptions,Chinese Pharmacopoeia,HUA BEING(www.huabeing.com),www.tcmdoc.cn,CNKI(www.cnki.net) and WANFANG DATA(www.wanfangdata.com.cn),for TCM prescriptions and modern composition patents of TCM containing Nardostachyos Radix et Rhizoma. Excel 2019 and SPSS software packets including Modeler 18.0 and Statistics 25.0 were used to conduct frequency statistics,association rules analysis and hierarchical cluster analysis of the drug composition. Results A total of 372 recipes of TCM prescriptions containing Nardostachyos Radix et Rhizoma were finally included,involving 374 documented drugs in Part I of the Chinese Pharmacopoeia. The top 10 drugs,with highest frequency of drug compatibility with Nardostachyos Radix et Rhizoma,were Baizhi(Angelicae Dahuricae Radix),Xiangfu(Cyperi Rhizoma),Gancao(Glycyrrhizae Radix et Rhizoma),Muxiang(Aucklandiae Radix),Chuanxiong(Chuanxiong Rhizoma),Xixin(Asari Radix et Rhizoma),Shannai(Kaempeeriae Rhizoma),Dingxiang(Caryophylli Flos),Danggui(Angelicae Sinensis Radix),and Sharen(Amomi Fructus),mostly falling into the efficacy classification of drugs for relieving exterior disorder. These recipes were mostly used to treat diseases with spleen syndromes,and the core drug combination was Muxiang Fenqi recipe with modifications. A total of 1533 patents of TCM composition containing Nardostachyos Radix et Rhizoma were eventually involved,referring 565 documented drugs in Part I of the Chinese Pharmacopoeia. The top 10 drugs,with highest frequency of drug compatibility with Nardostachyos Radix et Rhizoma,were Glycyrrhizae Radix et Rhizoma,

关 键 词：甘松 中医药 数据挖掘 频次统计 关联规则 聚类分析 

分 类 号：R285[医药卫生—中药学]