深圳地区41株Ca-MRSA流行特征与耐药性  

Epidemiological Characteristics and Antibiotics Resistance of 41 Ca-MRSA in Shenzhen Area

作　　者：周桂保 陈秋玲 谢培雯 李凯 陈晓文[1] 谢守霞 ZHOU Guibao;CHEN Qiuling;XIE Peiwen;LI Kai;CHEN Xiaowen;XIE Shouxia(Department of Pharmacy,Shenzhen People's Hospital,the Second School of Medicine,Jinan University,Shenzhen,Guangdong 518020,China;College of Pharmacy,Guangdong Medical University,Dongguan,Guangdong 523000,China)

机构地区：[1]暨南大学第二临床医学院,深圳市人民医院药学部,广东深圳518020 [2]广东医科大学药学院,广东东莞523000

出　　处：《今日药学》2021年第6期474-476,共3页Pharmacy Today

基　　金：广东省医院药学研究基金(2021A23)。

摘　　要：目的了解深圳地区Ca-MRSA流行特征及耐药性。方法调查深圳某医院2016~2018年Ca-MRSA检出率、标本来源及其对常见药物的耐药性。结果该院3年内分离Ca-MRSA共41株,检出率呈逐年上升趋势:2016年为10.00%,2017年为22.54%,2018年为26.87%。68.29%菌株分离自组织分泌物,其次为血液和痰液(均为12.20%)。Ca-MRSA对克林霉素、红霉素、环丙沙星及庆大霉素的耐药率分别为62.50%、63.41%、14.63%、4.88%,均低于HA-MRSA,而对多西环素的耐药率为26.32%,高于HA-MRSA,差异均有统计学意义。结论Ca-MRSA检出率逐年升高,且耐药性相对严重,需要加强监测。OBJECTIVE To explore epidemiological characteristics and antibiotics resistance of Ca-MRSA in Shenzhen area.METHODS We investigated the detected proportion of Ca-MRSA,specimen source and results of antimicrobial susceptibility test in a hospital from January 2016 to December 2018.RESULTS A total of 41 Ca-MRSA isolates were cultured and the isolated proportion of Ca-MRSA increased from 2016 to 2018:10.00%in 2016,22.54%in 2017,26.87%in 2018.63.41%Ca-MRSA were isolated from wound tissue secretions followed by blood and sputum(12.20%).Resistant rates of Ca-MRSA to clindamycin,erythromycin,ciprofloxacin,and gentamicin were 62.50%,63.41%,14.6%and 4.88%respectively,all of which were lower than HA-MRSA.Resistant rates of Ca-MRSA to doxycycline was 26.32%,which was higher than HA-MRSA.And these differences were statistically significant.CONCLUSION The detection proportion of Ca-MRSA is increasing year by year and its resistance is serious,so it is necessary to strengthen monitoring of Ca-MRSA.

关 键 词：CA-MRSA HA-MRSA 耐药性 合理用药 

分 类 号：R37[医药卫生—病原生物学]