体外受精患者不孕心理压力和皮质醇水平的相关性分析  

Correlation between Infertility Pressure and Cortisol Level in Women with In Vitro Fertilization

作　　者：周鹏飞[1] 王承秀 ZHOU Peng-fei;WANG Cheng-xiu(Department of Laboratory Medicine,Baoji Maternal and Child Health Hospital,Baoji 721000)

机构地区：[1]宝鸡市妇幼保健院检验科,陕西宝鸡721000 [2]陕西省镇安县医院妇产科,陕西镇安711500

出　　处：《医学临床研究》2021年第6期817-819,共3页Journal of Clinical Research

基　　金：陕西省重点研发计划项目(编号:2021SF-211)。

摘　　要：【目的】探讨体外受精(IVF)患者不孕心理压力和皮质醇(COR)水平的相关性。【方法】选取2018年6月至2020年1月在宝鸡市妇幼保健院生殖中心接受IVF治疗的不孕患者237例。采用生育压力量表(Fertility Problem Inventory,FPI)评估IVF患者的不孕压力评分;采用化学免疫发光分析法检测IVF患者血清COR水平;采用Pearson分析IVF患者的不孕压力与血清COR水平的相关性;采用Logistic回归分析IVF患者妊娠结局的危险因素。【结果】IVF患者不孕压力评分为(183.47±24.27)分,血清COR水平为(4.73±0.26)ng/mL。IVF患者不孕压力评分与血清COR水平呈正相关(r=0.878,P<0.05)。行IVF治疗的237例不孕患者的总受精率为65.71%,临床妊娠率为51.24%。多因素Logistic回归分析显示:不孕压力和血清COR水平是总受精率与临床妊娠率的影响因素(P<0.05)。【结论】接受IVF治疗患者具有较高的不孕压力和COR水平,且不孕心理压力评分和血清COR水平是IVF患者总受精率与临床妊娠率的影响因素。【Objective】To investigate the correlation between infertility pressure and cortisol level(COR)in women undergoing in vitro fertilization(IVF).【Methods】During June 2016 and January 2018,237 couples who received IVF or intracytoplasmic sperm injection(ICSI)in our reproductive center were included in the study.Fertility Problem Inventory(FPI)was used to measure the infertility pressure of the subjects.Serum cortisol levels were measured by chemiluminescence assay.Pearson's correlation was used to compare the correlation between infertility pressure and serum cortisol level.Logistic regression was used to analyze the risk factors of pregnancy outcome in IVF patients.【Results】The average age of 237 women was(33.8±4.3)years old.The BMI was(24.14±3.17)kg/m^(2),and the infertility time was(2.73±1.14)years.The infertility pressure score of IVF patients was(183.47±24.27)points,and the serum COR level was(4.73±0.26)ng/mL.The correlation analysis showed that infertility pressure score was positively correlated with serum cortisol level(P<0.05,with Pearson's correlation coefficient r=0.878).The total fertilization rate of 237 infertile patients undergoing IVF treatment was 65.71%,and the clinical pregnancy rate was 51.24%.Multivariate logistic regression analysis showed that aged≥30 years old,smoking,alcohol consumption,high infertility pressure,and high serum cortisol level were independent risk factors for in vitro fertilization and clinical pregnancy failure(P<0.05).【Conclusion】Women receiving IVF treatment have higher infertility pressure and cortisol levels.Fertilization rate and clinical pregnancy rate decreased with the increase of infertility pressure and cortisol level.

关 键 词：体外受精/方法 不育 女(雌)性 氢化可的松 妊娠率 

分 类 号：R714.13[医药卫生—妇产科学]