Elevated levels of serum antibodies against alpha-1,6-glucan in patients with systemic lupus erythematosus or rheumatoid arthritis  

作　　者：Hui Dai Xiao-Ming Gao 

机构地区：[1]Department of Immunology,Peking University Health Science Center,Peking University,Beijing 100083,China [2]Institute of Biology and Medical Sciences,Soochow University,Suzhou 215123,China

出　　处：《Protein & Cell》2011年第9期739-744,共6页蛋白质与细胞（英文版）

基　　金：supported by grants from the National Key Basic Research Program(Grant No.2007CB512406);the National High Technology Research and Development Program of China(863 Program)(Grant No.2006AA02Z495);the National Natural Science Foundation of China(Grant No.30371303).

摘　　要：This study was undertaken to investigate whether levels of anti-alpha-1,6-glucan antibodies in human sera correlate with rheumatoid arthritis(RA)and systemic lupus erythematosus(SLE).Serum samples were collected from patients with SLE(n=30),RA(n=30)and healthy adult volunteers.IgG,IgA and IgM levels against alpha-1,6-glucan were measured using enzyme linked immunosorbent assays.Anti-alpha-1,6-glucan IgG prevalence was raised in patients with active SLE(73.3%)and RA(60%)compared with healthy controls(13.3%).Strong correlation between anti-alpha-1,6-glucan-IgG levels and anti-perinuclear factor(r=0.642;p<0.05)in RA patients or anti-nuclear antibodies(r=0.675;p<0.05)in SLE patients was observed.No significant differences in anti-alpha-1,6-glucan-IgA or-IgM levels were noted between different groups.We conclude that anti-alpha-1,6-glucan-IgG levels were significantly elevated in patients with SLE or RA and positively correlated with disease activity.

关 键 词：AUTOANTIBODY anti-alpha-1 6-glucan autoimmune diseases systemic lupus erythematosus rheumatoid arthritis 

分 类 号：R59[医药卫生—内科学]