MTHFR基因多态性与中国男性不育关系的meta分析  

Association between MTHFR gene polymorphisms and Chinese male infertility:a meta-analysis

作　　者：周青 刘帅妹 张瑞金 石慧 林宁 吴玉璘 ZHOU Qing;LIU Shuaimei;ZHANG Ruijin;SHI Hui;LIN Ning;WU Yulin(Jiangsu Health Development Research Center,Nanjing,Jiangsu Province,210036)

机构地区：[1]江苏省卫生健康发展研究中心,南京210036

出　　处：《中国计划生育学杂志》2021年第5期860-863,共4页Chinese Journal of Family Planning

基　　金：江苏省科技厅创新能力建设计划(科技设施类)-省属公益类科研院所自主科研经费(省科技厅,BM2018033-3)。

摘　　要：目的:探讨亚甲基四氢叶酸还原酶(MTHFR)基因多态性与中国男性不育的关系。方法:通过检索中英文数据库,截止时间至2020年12月18日,经筛选最终纳入19篇文献。采用State软件计算OR和95%可信度区间,并进行异质性、敏感性分析和发表偏倚的评估。结果:5种遗传模型T比C(OR=1.51,95%CI1.34~1.71)、TC比CC(OR=1.13,95%CI 1.09~1.18)、TT比CC(OR=2.18,95%CI 1.72~2.76)、TT比(CC+CT)(OR=1.81,95%CI 1.51~2.17)和(TT+CT)比CC(OR=1.57,95%CI 1.34~1.84),MTHFR(C677T)基因多态性与中国男性不育存在明显相关性。结论:MTHFR(C677T)基因多态性可能增加中国男性不育的风险。Objective:To investigate the association between methylene tetrahydrofolate reductase gene polymorphism and male infertility in China.Methods:Chinese and English databases were searched until December 18,2020 and a total of 19 papers included in this meta-analysis.Odds ratio,95%confidence interval,heterogeneity,sensitivity analysis,and publication bias were calculated to evaluate the association between methylene tetrahydrofolate reductase gene polymorphism and male infertility by State software.Results:There were significant associations in the comparison T vs.C(OR=1.51,95%CI1.34-1.71),TC vs.CC(OR=1.13,95%CI 1.09-1.18),TT vs.CC(OR=2.18,95%CI1.72-2.76),TT vs.(CC+CT)(OR=1.81,95%CI1.51-2.17),and(TT+CT)vs.CC(OR=1.57,95%CI:1.34-1.84),which showed that MTHFR(C677 T)gene polymorphism was significantly associated with male infertility in China.Conclusion:MTHFR(C677 T)gene polymorphisms may increase the risk of male infertility in China.

关 键 词：男性不育 基因多态性 亚甲基四氢叶酸还原酶 

分 类 号：R698.2[医药卫生—泌尿科学]