PCOS患者血清CTRP9与糖脂代谢、总睾酮、体质指数及胰岛功能的相关性  

Correlation between the serum CTRP9 level of women with polycystic ovary syndrome and their levels of glucose and lipid metabolism,and total testosterone,body mass index value,and islet function

作　　者：刘晓艳 汪莹[2] LIU Xiaoyan;WANG Yingzhan(Fengnan Hospital of Tangshan,Hebei Province,063000;Tangshan Maternal and Child Health Hospital)

机构地区：[1]河北省唐山市丰南区医院,063000 [2]河北省唐山市妇幼保健院

出　　处：《中国计划生育学杂志》2021年第5期1000-1003,共4页Chinese Journal of Family Planning

摘　　要：目的:分析多囊卵巢综合征(PCOS)患者血清C1q/肿瘤坏死因子相关蛋白9(CTRP9)与糖脂代谢、总睾酮(T)、体质指数(BMI)及胰岛功能的相关性。方法:选取2019年1-12月在本院诊治的PCOS患者103例为PCOS组,同期健康体检女性103例为对照组。比较两组血清CTRP9、糖脂代谢、TT、BMI、胰岛功能,分析其对PCOS的影响及相关性。结果:PCOS组血清CTRP9、高密度脂蛋白胆固醇(HDL-C)低于对照组,血清空腹血糖(FPG)、餐后2h血糖(2hPBG)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、游离脂肪酸(FFA)、BMI、T、空腹胰岛素(FINS)、胰岛β细胞分泌指数(HOMA-β)、稳态胰岛素评价指数(HOMA-IR)高于对照组(P<0.05)。经Pearson分析,血清CTRP9与HDL-C呈正相关,与FPG、2hPBG、TG、LDL-C、FFA、BMI、T、FIN、HOMA-IR、HOMA-β呈负相关(P<0.05)。经多因素分析,FPG、2hPBG、TG、LDL-C、FFA、BMI、T、FIN、HOMA-IR、HOMA-β均是影响PCOS的危险因素,CTRP9、HDL-C是影响PCOS的保护因素。结论:PCOS患者血糖升高、脂质代谢紊乱,T和BMI升高,胰岛功能紊乱,均会导致血清CTRP9降低,影响疾病进程。Objective:To analyze the correlation of the level of serum Clq/tumor necrosis factor-related protein 9(CTRP9)of women with polycystic ovary syndrome(PCOS)with their levels of glucose and lipid metabolism and total testosterone(TT),body mass index(BMI)value,and islet function.Methods:103 women with PCOS were selected in study group from January 2019 to December 2019,and 103 healthy women were selected in control group during the same period.The levels of serum CTRP9,glucose and lipid metabolism,and TT,BMI value,and islet function of the women were compared between the two groups,and its effect on PCOS and the correlation of the serum CTRP9 level with the levels of glucose and lipid metabolism,and TT,BMI value,and islet function were analyzed.Results:The serum CTRP9 and high-density lipoprotein cholesterol(HDL-C)levels of the women in the study group were significant lower than those of the women in the control group(P<0.05).The levels of serum fasting blood glucose(FPG),2 h postprandial blood glucose(2 hPBG),triacylglycerol(TG),low-density lipoprotein cholesterol(LDL-C),free fatty acids(FFA),TT,and fasting insulin(FINS),and the values of BMI,pancreaticβ-cell secretion index(HOMA-β),and steady state insulin evaluation index(HOMA-IR)of the women in the study group were significant higher than those of the women in the control group(P<0.05).According to Pearson analysis had showed that the level of serum CTRP9 was positive correlated with HDL-C level,but was negative correlated with the FPG level,2 hPBG level,TG level,LDL-C level,FFA level,BMI value,TT level,FIN level,HOMA-IR value,or HOMA-βvalue were correlated(P<0.05).Multi-factor analysis had showed that FPG level,2 hPBG level,TG level,LDL-C level,FFA level,BMI value,TT level,FIN level,HOMA-IR value,HOMA-βvalue were all the risk affecting factors of PCOS,and CTRP9 level and HDL-C level were the protective factors of PCOS.Conclusion:The blood glucose level of the women with PCOS increases,their lipid metabolism disorders,their TT level and BMI value increase,an

关 键 词：多囊卵巢综合征 肿瘤坏死因子相关蛋白 糖脂代谢 总睾酮 胰岛功能 

分 类 号：R711.75[医药卫生—妇产科学]