子痫前期孕妇肾脏血流超声参数与血清氧化应激指标的相关性  

Correlation between the ultrasonic parameters of renal blood flow of pregnant women with preeclampsia and their serum oxidative stress indicator

作　　者：门晓玉[1] 黄小艳[1] 陈珂珂[1] 张霞[1] MEN Xiaoyu;HUANG Xiaoyan;CHEN Keke;ZHANG Xia(The First People's Hospital of Shangqiu,Henan Province,476100)

机构地区：[1]河南省商丘市第一人民医院,476100

出　　处：《中国计划生育学杂志》2021年第5期1008-1011,共4页Chinese Journal of Family Planning

摘　　要：目的:分析不同严重程度子痫前期(PE)孕妇肾脏血流超声参数的改变及其与血清氧化应激指标的相关性。方法:选择2017年1月-2019年12月本院收治的PE患者77例,分为非重度组49例与重度组28例,应用二维及三维能量多普勒超声检测并比较肾脏动脉阻力指数(RI)、搏动指数(PI)、收缩期流速峰值/舒张末期流速峰值(S/D)及肾脏血管指数(VI)、血流指数(FI)及血管血流指数(VFI),检测并比较两组血清丙二醛(MDA)、晚期蛋白氧化产物(AOPPs)、脂质过氧化氢(LHP)、总抗氧化能力(T-AOC)水平,分析肾脏超声血流参数与血清氧化应激指标的相关性。结果:重度组肾脏动脉RI、PI、S/D值大于非重度组,VI、FI、VFI值小于非重度组(P均<0.05);重度组血清MDA、AOPPs、LHP值大于非重度组,血清T-AOC值小于非重度组(P均<0.05)。血清MDA、AOPPs、LHP水平与肾脏动脉RI值呈正相关(P<0.001),T-AOC与肾脏动脉RI值呈负相关(P<0.05);AOPPs水平与肾脏动脉PI值呈正相关(P<0.05),T-AOC与肾脏动脉S/D值呈负相关(P<0.05);MDA、LHP与肾脏动脉RI、S/D值无相关关系,血清T-AOC水平与肾脏动脉PI值无相关关系(均P>0.05)。血清MDA、AOPPs、LHP水平与肾脏FI、VFI值呈负相关,T-AOC水平与肾脏FI、VFI值呈正相关(P均<0.05);AOPPs水平与肾脏VI值呈负相关(P<0.05),MDA、LHP、T-AOC水平与肾脏VI值无相关关系(P均>0.05)。结论:PE患者氧化应激损伤指标异常与肾脏血流灌注的减少有关,有望成为评估肾脏损伤的参考指标。Objective: To analyze the changes of ultrasonic parameters of renal blood flow of pregnant women with different severity of preeclampsia(PE), and to study its correlation with their serum oxidative stress indicator. Methods: 77 pregnant women with PE were selected and divided into group A(49 women without severe PE) and group B(28 women with severe PE) from January 2017 to December 2019. The renal artery resistance index(RI), pulse index(PI), peak systolic velocity/peak end-diastolic velocity(S/D), renal vascular index(VI), blood flow index(FI), and blood vessel flow index(VFI) of the women in the two groups were detected by two-dimensional and three-dimensional energy Doppler ultrasound. Serum levels of malondialdehyde(MDA), advanced protein oxidation products(AOPPs), lipid hydrogen peroxide(LHP) and total antioxidant capacity(T-AOC) of the women were detected by ELISA and were compared between the two groups. The correlation between ultrasonic parameters of renal blood flow and the levels of serum oxidative stress indicators was analyzed. Results: The values of RI, PI and S/D of renal artery of the women in group B were significant higher than those of the women in group A, while the values of VI, FI and VFI of the women in group B were significant lower(all P<0.05). The serum MDA, AOPPs and LHP levels of the women in group B were significant higher than those of the women in group A, but the serum T-AOC level of the women in group B was significant lower(all P<0.05). The serum levels of MDA, AOPPs and LHP were positive correlated with the RI value of renal artery(P<0.001),and the T-AOC level was negative correlated with the RI value of renal artery(P<0.05).The level of AOPPs was positive correlated with the PI value of renal artery(P<0.05),and the T?AOC level was negative correlated with the S/D value of renal artery(P<0.05).The MDA and LHP levels was no correlation with the values of RI and S/D of renal artery,and the serum T-AOC level was no correlation with PI value of renal artery(all P>0.05).The serum MDA

关 键 词：子痫前期 肾脏 血流超声参数 氧化应激指标 

分 类 号：R714.244[医药卫生—妇产科学] R445.1[医药卫生—临床医学]