孕期B族链球菌感染对胎膜早破和新生儿影响及药敏分析  

Effect of group B streptococcus infection during pregnancy on premature rupture of membranes and neonates and drug sensitivity

作　　者：黄晓林 严静静[1] HUANG Xiaolin;YAN Jingjing(Jiangning hospital of Nanjing,Jiangsu Province,211100)

机构地区：[1]江苏省南京市江宁医院,211100

出　　处：《中国计划生育学杂志》2021年第5期1041-1045,共5页Chinese Journal of Family Planning

摘　　要：目的:探讨分析孕期B族链球菌(GBS)感染对于胎膜早破和新生儿不良结局影响及药敏实验。方法:收取本院自2018年1-8月收治的接受GBS筛查的孕妇1266例,其中220例为胎膜早破孕妇为观察组,余1046例为对照组。比较两组孕妇GBS检测结果及新生儿结局;对感染孕妇实施抗感染干预。结果:GBS阳性率观察组(12.3%)高于对照组(5.5%)。GBS感染组(85例)胎膜早破、产褥感染、宫内感染、产后出血等妊娠不良事件发生率高于非感染组(1181例),新生儿感染、胎儿窘迫、新生儿窒息、新生儿肺炎等总发生率(23.5%)高于非感染组(8.8%),新生儿娩出后1min、5min Apgar评分(7.0±0.8分、8.4±1.7分)均低于非感染组(8.2±1.3分、9.0±2.0分)(均P<0.05)。感染组药敏试验结果显示,青霉素(95.3%)与头孢菌素(91.8%)敏感性更高,而克林霉素(72.9%)、阿米卡星敏感性(70.6%)较低。感染孕妇经护理干预后满意度达到100%。结论:孕期GBS感染会增加新生儿围生期不良事件及胎膜早破发生风险;待分娩孕妇确诊感染后需行药敏实验,并选择针对性抗生素药物及护理措施进行干预,降低胎膜早破发生率,改善母婴不良结局。Objective: To explore the effect of group B streptococcus(GBS) infection of women during pregnancy on premature rupture of membranes and neonates, and to study drug sensitivity. Methods: 1266 pregnant women who had received GBS screening were enrolled in this study from January 2018 to August 2018, and which included 220 women with premature rupture of membranes in observation group and 1046 women without premature rupture in control group. The detection result of GBS and neonatal outcomes were compared between the two groups. In addition, anti-infection intervention was given the women in the observation group. Results: The positive rate of GBS(12.3%) of the women in the observation group was significant higher than that(5.5%) of the women in the control group. The rates of premature rupture of membranes, puerperal infection, intrauterine infection, postpartum hemorrhage, and other adverse pregnancy of 85 women with GBS infection were significant higher than those of 1181 women without GBS infection. The total incidence(neonatal infection, fetal distress, neonatal asphyxia, and pneumonia of newborn) of the women with GBS infection(23.5%) was significant higher than that(8.8%) of the women without GBS infection. The neonatal Apgar score 1 min and 5 min after born(7.0±0.8 points, 8.4±1.7) of the women with GBS infection were significant lower than those(8.2±1.3 points and 9.0±2.0 points) of the women without GBS infection(all P<0.05). The results of drug sensitivity test of the women with GBS infection showed that penicillin(95.3%) and cephalosporin(91.8%) were more sensitive, while clindamycin(72.9%) and amikacin(70.6%) were less sensitive. After nursing intervention, the satisfaction of the women with GBS infection was 100%. Conclusion: GBS infection of the women during pregnancy will increase the risk of neonatal adverse events and premature rupture of membranes.Therefore,drug sensitivity test should be performed immediately after the diagnosis of pregnant women infection,and targeted antibiotics treatment

关 键 词：孕妇 B族链球菌 护理干预 胎膜早破 新生儿 不良结局 药敏试验 

分 类 号：R714.433[医药卫生—妇产科学]