慢性肝病血小板减少的原因  

Causes of thrombocytopenia in chronic liver diseases

作　　者：李尚书 刘群[1] 黄丽雯[2] Li Shangshu;Liu Qun;Huang Liwen(Department of Gastroenterology,Tianyou Hospital,Wuhan University of Science and Technology,Wuhan 430061,China;Department of Integrative Medicine,Tianyou Hospital,Wuhan University of Science and Technology,Wuhan 430061,China)

机构地区：[1]武汉科技大学附属天佑医院消化内科,武汉430061 [2]武汉科技大学附属天佑医院中西医结合科,武汉430061

出　　处：《中国肝脏病杂志（电子版）》2021年第2期24-28,共5页Chinese Journal of Liver Diseases：Electronic Version

基　　金：湖北省2016~2017年度中西医结合科研指导性项目(13)。

摘　　要：血小板减少是晚期肝病患者的常见并发症,是慢性肝病预后不良的独立预测因子。血小板减少可能会影响既定治疗方案的实施,严重者会增加出血风险。因此,了解慢性肝病血小板减少的机制并早期干预是必要的。慢性肝病血小板减少在过去被认为是脾功能亢进的结果。近年来,随着血小板生成素机制及血小板生成素受体激动剂的发现,研究人员对慢性肝病血小板减少有了新的理解。本文现对慢性肝病血小板减少的原因进行综述。Thrombocytopenia is a common complication of advanced liver diseases and an independent predictor of poor prognosis of chronic liver diseases.Sometimes,thrombocytopenia can affect the implement of the established treatment,which will increase the risk of bleeding in severe cases.Therefore,understanding the mechanism of thrombocytopenia in chronic liver diseases and early intervention are necessary.In the past,thrombocytopenia in chronic liver diseases was considered as the results of hypersplenism.With the discovery of the mechanism of thrombocytopenia and its receptor agonist in recent years,researchers have a new understanding of thrombocytopenia in chronic liver diseases.This paper summarized the causes of thrombocytopenia in chronic liver diseases.

关 键 词：肝病 慢性 血小板减少 脾功能亢进 

分 类 号：R575[医药卫生—消化系统]