Induced pluripotency and direct reprogramming:a new window for treatment of neurodegenerative diseases  

作　　者：Rui Li Ye Bai Tongtong Liu Xiaoqun Wang Qian Wu 

机构地区：[1]State Key Laboratory of Brain and Cognitive Science,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China

出　　处：《Protein & Cell》2013年第6期415-424,共10页蛋白质与细胞（英文版）

基　　金：the National Basic Research Program 973 program(No.2012CB966800);the Thousand Youth Talents Program and the Pioneer Programs of Chinese Academy of Sciences。

摘　　要：Human embryonic stem cells(hESCs)are pluripotent cells that have the ability of unlimited self-renewal and can be differentiated into different cell lineages,includ-ing neural stem(NS)cells.Diverse regulatory signaling pathways of neural stem cells differentiation have been discovered,and this will be of great benefit to uncover the mechanisms of neuronal differentiation in vivo and in vitro.However,the limitations of hESCs resource along with the religious and ethical concerns impede the pro-gress of ESCs application.Therefore,the induced pluri-potent stem cells(iPSCs)via somatic cell reprogramming have opened up another new territory for regenerative medicine.iPSCs now can be derived from a number of lin-eages of cells,and are able to differentiate into certain cell types,including neurons.Patient-specifi c iPSCs are being used in human neurodegenerative disease modeling and drug screening.Furthermore,with the development of somatic direct reprogramming or lineage reprogramming technique,a more effective approach for regenerative medicine could become a complement for iPSCs.

关 键 词：human embryonic stem cells(hESCs) neu-ronal differentiation induced pluripotent stem cells(iPSCs) somatic direct reprogramming lineage reprogramming regen-erative medicine 

分 类 号：R32[医药卫生—人体解剖和组织胚胎学]