米非司酮配伍不同药物治疗药物流产后宫腔残留效果  

Efficacy of mifepristone combined with different drugs for treatment of uterine cavity residues after medical induced abortion

作　　者：楚光华 刘晨 胡春艳 王伟强 王欣茹 CHU Guanghua;LIU Chen;HU Chunyan;WANG Weiqiang;WANG Xinru(Northwest Women and Children's Hospital,Xi'an,Shaanxi Province,710061)

机构地区：[1]西北妇女儿童医院,西安710061

出　　处：《中国计划生育学杂志》2021年第6期1100-1102,1108,共4页Chinese Journal of Family Planning

摘　　要：目的:探讨米非司酮配伍不同药物治疗药物流产术后宫腔残留的临床效果。方法:采用回顾性研究方法选取2016年1月1日-2017年12月31日于本院行药物流产后确诊为宫腔残并行药物保守治疗的312例为研究对象。根据治疗方法分为3组,比较3组治疗效果。结果:米非司酮联合缩宫素喷雾组和联合缩宫素肌注组治疗成功率显著高于联合益母草胶囊组(P<0.05);米非司酮联合缩宫素喷雾组与联合缩宫素肌注组出血时间及出血量均显著低于联合益母草胶囊组(P<0.05);3组hCG阴转率及阴转时间无统计学差异(P>0.05)。米非司酮联合缩宫素喷雾组与联合益母草胶囊组用药治疗的依从性及满意度均显著高于米非司酮联合缩宫素肌注组(P<0.05)。3组治疗过程中,均未发生严重不良反应,不良反应率比较无统计学差异(P>0.05)。结论:米非司酮联合缩宫素肌注或联合缩宫素鼻喷雾均可有效促进宫腔残留物的排出,米非司酮联合缩宫素鼻喷雾患者的依从性及满意度更高。Objective: To investigate the clinical effect of mifepristone combined with different drugs for treating uterine cavity residues after medical induced abortion. Methods: A retrospective study was used to select 312 women who had been diagnosed as uterine cavity residues after induced abortion and had been treated by drugs conservatively from January 1, 2016 to December 31, 2017. According to the treatment methods, these women were divided into three groups, and the therapeutic effects of the women in the three groups were compared. Results: The success rate of the therapy by mifepristone combined with oxytocin spray or oxytocin intramuscular injection was significant higher than that by mifepristone combined with motherwort capsule(P<0.05). The bleeding time and amount after the therapy by mifepristone combined with oxytocin spray or oxytocin intramuscular injection were significant less than thoase by mifepristone combined with motherwort capsule treatment(P<0.05). There were no significant differences in negative conversion rate and negative conversion time of hCG among the three groups(P>0.05). The compliance and satisfaction of the therapy by mifepristone combined with oxytocin spray or motherwort capsule was significant higher than that by mifepristone combined with oxytocin intramuscular injection(P<0.05). No serious adverse reactions occurred in the three groups during treatment, and there was no significant difference in adverse reaction rate among the three groups(P>0.05). Conclusion: Mifepristone combined with oxytocin intramuscular injection or oxytocin nasal spray can effectively promote the discharge of uterine cavity residues, and the treatment compliance and satisfaction of the women by mifepristone combined with oxytocin nasal spray are higher.

关 键 词：药物终止妊娠术 宫腔残留 米非司酮 缩宫素 疗效 

分 类 号：R169.42[医药卫生—公共卫生与预防医学]