沙丁胺醇治疗妊娠期子宫肌瘤红色变性对患者血清IGF-1、Ang-2及分娩结局的影响  

Effect of salbutamol for treating pregnant women with red degeneration of uterine fibroids during pregnancy on their levels of serum insulin-like growth factor 1 and angiopoietin 2 and their delivery outcomes

作　　者：王旭慧[1] 周艳艳[1] 孙岩[1] WANG Xuhui;ZHOU Yanyan;SUN Yan(Qingdao Municipal Hospital Qingdao,Shandong Province,266000)

机构地区：[1]青岛市市立医院,266000

出　　处：《中国计划生育学杂志》2021年第6期1163-1166,共4页Chinese Journal of Family Planning

摘　　要：目的:探讨沙丁胺醇对妊娠期子宫肌瘤红色变性患者血清胰岛素样生长因子1(IGF-1)、血管生成素2(Ang-2)及分娩结局的影响。方法:选择2019年1月-2020年1月在本院接受治疗的妊娠期子宫肌瘤红色变性患者87例,采用随机数表法分为观察组(n=44)和对照组(n=43)。对照组给予硫酸镁治疗,观察组给予沙丁胺醇治疗。比较两组临床疗效、血清IGF-1、Ang-2、围产期临床指标、分娩结局及不良反应发生情况。结果:治疗后,观察组总有效率(90.9%)高于对照组(74.4%)(P<0.05);两组血清IGF-1、Ang-2水平均随治疗时间的推移而下降且观察组低于对照组,体温恢复、恶露干净、宫缩消失及产后腹痛消失时间观察组低于对照组(P<0.05);观察组不良分娩结局(9.1%)低于对照组(30.2%),不良反应总发生率(9.1%)低于对照组(27.9%)(均P<0.05)。结论:应用沙丁胺醇治疗妊娠期子宫肌瘤红色变性效果显著,可有效降低患者血清IGF-1、Ang-2水平,安全性较好。Objective: To study the effect of salbutamol for treating pregnant women with red degeneration of uterine fibroids during pregnancy on their levels of serum insulin-like growth factor 1(IGF-1), angiopoietin 2(ANG-2) and their delivery outcomes. Methods: 87 pregnant women with red degeneration of uterine fibroids during pregnancy were selected and divided into observation group(n=44) and control group(n=43) by random number table method from January 2019 to January 2020. The women in the control group were treated with magnesium sulfate and the women in the observation group with salbutamol. Clinical efficacy, serum IGF-1 and Ang-2 levels, perinatal clinical indicators, delivery outcomes, and the incidence of adverse reactions of the women were compared between the two groups. Results: After treatment, the total effective rate(90.9%) of the women in the observation group was significant was higher than that(74.4%) of the women in the control group(P<0.05). Serum IGF-1 and Ang-2 levels of the women in two groups had decreased with the treatment time significantly, and which of the women in the observation group was significant lower than those of the women in the control group. The time of body temperature recovery, time of lochia disappeared, disappearance of uterus contractions and postpartum abdominal pain of the women in the observation group were significant lower than those of the women in the control group(P<0.05). The rate of adverse pregnancy outcomes(9.1%) of the women in the observation group was significant lower than that(30.2%) of the women in the control group, and the total incidence of adverse reactions(9.1%) of the women in the observation group was significant lower than that(27.9%) of the women in the control group(all P<0.05). Conclusion: Salbutamol for treating pregnant women with red degeneration of uterine fibroids during pregnancy has good effectiveness, which can effectively decrease serum IGF-1 and Ang-2 levels with better safety.

关 键 词：妊娠 子宫肌瘤红色变性 沙丁胺醇 胰岛素样生长因子1 血管生成素2 分娩结局 

分 类 号：R737.33[医药卫生—肿瘤]