子宫内膜异位症合并不孕患者血清miR-145表达及与临床病理类型及妊娠结局关系  

Expression of serum miR-145 level of infertility women with endometriosis,and its association with clinicopathological type and pregnancy outcomes

作　　者：陶中娥[1] 张晔 TAO Zhonge;ZHANG Ye(The First Central Hospital of Tianjin,Tianjin,300070)

机构地区：[1]天津市第一中心医院,300070

出　　处：《中国计划生育学杂志》2021年第6期1266-1269,共4页Chinese Journal of Family Planning

摘　　要：目的:探讨子宫内膜异位症(EMT)合并不孕患者血清miR-145表达与临床病理类型及妊娠结局关系。方法:2017年1月-2019年12月在本院接受腹腔镜及药物治疗的EMT合并不孕患者122例作为EMT合并不孕组,同期体检正常的育龄女性100例为正常对照组,对比两组及EMT合并不孕组不同临床病理类型患者血清miR-145表达差异。分析EMT合并不孕患者术前血清miR-145表达预测术后妊娠结局价值。结果:EMT合并不孕组术前血清miR-145(0.78±0.12)高于正常对照组(0.56±0.09),且术后(0.67±0.10)高于术前(均P<0.05)。EMT合并不孕患者中,腺肌病型患者术前血清miR-145水平高于单纯腹膜型、内囊型患者(P<0.05),而单纯腹膜型与内囊型患者水平无差异(P>0.05)。高miR-145表达患者宫内妊娠率(42.6%)、累计妊娠率(54.1%)均低于低miR-145表达患者(63.9%、73.8%)(P<0.05)。ROC曲线显示,EMT合并不孕患者术前血清miR-145预测术后妊娠的最佳截断值为0.685,AUC为0.758(95%CI 0.6700.847),对应的灵敏度、特异度分别为70.5%、69.2%。结论:EMT合并不孕患者血清miR-145水平增高,且不同临床病理类型及妊娠结局患者表达水平存在差异,提示EMT合并不孕患者术前miR-145表达水平对术后妊娠结局有一定临床预测价值。Objective:To investigate the expression of serum miR-145 level of infertility women with endometriosis(EMT),and to study its association with clinicopathological type and pregnancy outcomes of the women.Methods:122 infertility women with EMT were selected in study group between January 2017 to December 2019,and 100 healthy women were selected in control group during the same period.The serum miR-145 expression level of the women was compared between the two groups,and was compared among the women with different clinical pathological types in the study group.The value of preoperative serum miR-145 level of the women in the study group for predicting their postoperative pregnancy outcomes was analyzed.Results:The serum miR-145 level(0.78±0.12)of the women before surgery in the study group was significant higher than that(0.56±0.09)of the women in the control group,and the serum miR-145 level of the women after surgery in the study group(0.67±0.10)was significant higher than that before surgery(all P<0.05).In the study group,the preoperative serum miR-145 level of the women with adenomyosis was significant higher than that of the women with peritoneal type EMT or internal capsule type EMT(P<0.05),while there was no significant difference in the level of serum miR-145 between the women with peritoneal type EMT and the women with internal capsule type EMT(P>0.05).The intrauterine pregnancy rate(42.6%)and cumulative pregnancy rate(54.1%)of the women with high miR-145 level were significant lower than those(63.9%and 73.8%)of the women with low miR-145 level(P<0.05).ROC curve showed that the optimal cutoff value of preoperative serum miR-145 level of the infertility women with EMT was 0.685,the area under the curve(AUC)was0.758(95%CI 0.670-0.847),and the sensitivity and the specificity were 70.5% and 69.2%,respectively.Conclusion:The level of serum miR-145 of infertility women with EMT increases,which is different in the women with different clinicopathological types and in the women with different pregnancy outcomes.

关 键 词：子宫内膜异位症 不孕 MIR-145 临床病理类型 妊娠结局 预测 

分 类 号：R711.71[医药卫生—妇产科学] R711.6[医药卫生—临床医学]