血浆Hcy、Cysc、hs-CRP水平对妊娠期高血压患者预后评估  

Analysis of the levels of plasma homocysteine,cystatin C,and high sensitivity C-reactive protein in prognosis evaluation of pregnant women with gestational hypertension

作　　者：陈婷婷 陈曦[1] CHEN Tingting;CHEN Xi(Mianyang Central Hospital,Sichuan Province,621000)

机构地区：[1]四川省绵阳市中心医院,621000

出　　处：《中国计划生育学杂志》2021年第6期1270-1272,共3页Chinese Journal of Family Planning

摘　　要：目的:探讨血浆同型半胱氨酸(Hcy)、胱抑素C(Cysc)、超敏C反应蛋白(hs-CRP)水平在妊娠期高血压(HDP)患者预后评估中的作用。方法:收集2019年1-12月本院收治的HDP患者126例临床资料为HDP组,同期正常孕妇126例为对照组。检测并两组孕妇血浆同型半胱氨酸(Hcy)、胱抑素C(Cysc)、超敏C反应蛋白(hs-CRP)水平,统计妊娠结局。结果:HDP组血浆Hcy(18.7±3.9 umol/L)、Cysc(1.5±0.5 mg/L)、hs-CRP水平(5.7±1.6 mg/L)大于对照组(5.1±1.4 umol/L、0.8±0.1 mg/L、2.5±0.5 mg/L)(P<0.05);不良妊娠结局发生(65.9%)高于对照组(18.3%)(P<0.05);血浆Hcy、Cysc、hs-CRP水平与HDP呈正相关(r=0.589、0.678、0.782,均P<0.05)。结论:对HDP患者预后评估时,检测血浆Hcy、Cysc、hs-CRP水平有一定临床意义。Objective: To study the levels of plasma homocysteine(Hcy), cystatin C(Cys C),and high sensitivity C-reactive protein(hs CRP) in prognosis evaluation of pregnant women with gestational hypertension. Methods: The clinical data of 126 pregnant women with gestational hypertension from January 2019 to December 2019 were collected and included in observation group, and 126 normal pregnant women were selected in control group during the same period. The plasma Hcy, Cys C,and hs (CRP) levels of the women in the two groups were detected and compared. The pregnancy outcomes of the women in the two groups were statistics analyzed. Results: The levels of plasma Hcy(18.7±3.9 umol/L), Cys C(1.5±0.5 mg/L), and hs-CRP(5.7±1.6 mg/L) of the women in the observation group were significant higher than those(5.1±1.4 umol/L, 0.8±0.1 mg/L, and 2.5±0.5 Mg/L) of the women in control group(P<0.05). The incidence of adverse pregnancy outcome(65.9%) of the women in the observation group was significant higher than that(18.3%) of the women in the control group(P<0.05). Plasma levels of Hcy, Cys C, and hs-CRP were positively correlated with the occurrence of gestational hypertension(r=0.589, 0.678, 0.782, all P<0.05). Conclusion: The detection of plasma Hcy, Cys C and hs-CRP levels has some clinical significance in the prognosis evaluation of pregnant women with gestational hypertension.

关 键 词：妊娠期高血压 血浆同型半胱氨酸 胱抑素C 超敏C反应蛋白 预后评估 

分 类 号：R714.246[医药卫生—妇产科学]