糖尿病胃轻瘫的发病机制和治疗研究进展  

Advances in Study on Pathogenesis and Treatment of Diabetic Gastroparesis

作　　者：谢浩然 廖红雨 龚晓媛 余兰婷 赵秋艳 李百文[1] XIE Haoran;LIAO Hongyu;GONG Xiaoyuan;YU Lanting;ZHAO Qiuyan;LI Baiwen(Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200080;Zhanang County Health Service Center, Xizang Autonomous Region)

机构地区：[1]上海交通大学附属第一人民医院消化内科,200080 [2]西藏自治区扎囊县卫生服务中心

出　　处：《胃肠病学》2020年第12期759-763,共5页Chinese Journal of Gastroenterology

基　　金：国家自然科学基金面上项目(81572316)。

摘　　要：糖尿病胃轻瘫(DGP)以胃肠动力减弱引起的胃排空延迟为特征,临床表现为呕吐、恶心、嗳气、早饱、餐后胞胀、腹胀等。其确切发病机制仍未明确,可能主要与Cajal间质细胞减少、平滑肌病变和神经病变有关。治疗方法以促胃动力药、胃电刺激、内镜治疗等对症治疗为主,但长期疗效不甚满意,患者生活质量受到严重影响。本文就DGP的发病机制和治疗研究进展作一综述。Diabetic gastroparesis(DGP)is characterized by delayed gastric emptying caused by reduction of gastrointestinal motility.Its clinical manifestations include vomiting,nausea,belching,early satiety,postprandial fullness,and abdominal distention,etc.The mechanism of DGP is still not clear.Depletion of interstitial cells of Cajal,myopathy and neuropathy are considered to be the main pathogenic factors.Gastric prokinetics,gastric electric stimulation and endoscopic therapy are the main treatment options,but the long-term efficacy of these symptomatic treatment is not very satisfactory,which seriously affects patients’quality of life.This article reviewed the advances in study on pathogenesis and treatment of DGP.

关 键 词：糖尿病 糖尿病并发症 胃肌轻瘫 发病机制 治疗 

分 类 号：R58[医药卫生—内分泌]