阴虚火旺型糖尿病患者睡眠障碍与血糖波动、25-羟基维生素D等因素的相关性  

Correlation analysis of sleep disorder of diabetic patients with Yin deficiency and Huowang and blood glucose fluctuation,25 hydroxyvitamin D

作　　者：姜群群[1] 王思明[1] JIANG Qunqun;WANG Siming(Endocrinology Department,the 970th People′s Liberation Army,Yantai 264100,Shandong,P.R.China)

机构地区：[1]中国人民解放军联勤保障部队第九七○医院内分泌科,山东烟台264100

出　　处：《滨州医学院学报》2021年第3期207-210,共4页Journal of Binzhou Medical University

摘　　要：目的了解阴虚火旺型糖尿病患者的睡眠障碍的相关因素。方法收集阴虚火旺型糖尿病合并睡眠障碍患者150例作为实验组,不伴有睡眠障碍患者150例作为对照组,比较两组患者一般临床资料、血糖波动情况、低血糖发生率。结果睡眠障碍组患者的收缩压(SBP)、舒张压(DBP)、空腹血糖(FPG)、低密度脂蛋白胆固醇(LDL-C)均高于睡眠正常组,身体质量指数(BMI)、25-羟基维生素D25(OH)D低于睡眠正常组,P<0.05;对两组患者的糖化血红蛋白A1c(HbA1c)、血糖标准差(SDBG)、餐后血糖波动幅度(PPGE)、最大血糖波动幅度(LAGE)进行比较,P<0.05。logistic回归结果提示HbA1c、PPGE、SBP、FPG及低血糖发生与阴虚火旺型糖尿病伴睡眠障碍有正相关性,P<0.05;25(OH)D与阴虚火旺型糖尿病伴睡眠障碍有负相关性,P<0.05。结论阴虚火旺型糖尿病患者血糖、血压不能得到有效积极的控制,血糖波动较大,易出现低血糖的患者,睡眠障碍的发生率升高。Objective To analyze retrospectively the clinical data of diabetes mellitus with Yin deficiency and fire hyperactivity in order to understand the correlation of sleep disorders in diabetic patients.Methods One hundred and fifty cases of diabetes mellitus with sleep disorder and 150 cases without sleep disorder were collected as the control group.The general clinical data,blood glucose fluctuation and incidence of hypoglycemia were compared between the two groups.Results SBP,DBP,fasting blood glucose,in the sleep disorder group were significantly higher than those in the normal sleep group,with statistical significance,P<0.05;the HbA1c,SDBG,PPGE and LAGE in the two groups were compared,with statistical significance,P<0.05.The results of logistic regression showed that HbA1c,PPGE,SBP,FPG and hypoglycemia were positively correlated with sleep disorder in Yin deficiency Huowang type diabetes mellitus,P<0.05,and 25(OH)D was positively correlated with sleep disorder in Yin deficiency Huowang type diabetes mellitus,P<0.05.Conclusion As the blood glucose and blood pressure of patients with Yin deficiency and Huowang type diabetes can not be effectively and actively controlled,the blood glucose fluctuates greatly,patients are prone to hypoglycemia,and the incidence of sleep disorders increases gradually.

关 键 词：阴虚火旺 糖尿病 睡眠障碍 血糖波动 25-羟基维生素D 相关性 

分 类 号：R587.1[医药卫生—内分泌]