三七花皂苷调控细胞离子通道的研究进展  

Research Progress of Panax notoginseng Flower Saponins in Regulating Cell Ion Channels

作　　者：钟飞 杜娅娅 李梦婷 许正新[1,2,3,4] ZHONG Fei;DU Ya-ya;LI Meng-ting;XU Zheng-xin(Department of Pharmacology,School of Medicine,Yangzhou University,Yangzhou 225000,China;Jiangsu Key Laboratory of Animal Infectious Diseases and Zoonosis Prevention and Control,Yangzhou 225001,China;Key Laboratory of Integrative Medicine Prevention and Treatment in Jiangsu Province Room,Yangzhou 225001,China;Jiangsu Key Laboratory of Non-coding RNA Basic and Clinical Transformation,Yangzhou 225009,China)

机构地区：[1]扬州大学医学院药学系,江苏扬州225000 [2]江苏省重点动物传染病和人畜共患病预防控制共创中心,江苏扬州225001 [3]江苏省中西医结合老年病防治重点实验室,江苏扬州225001 [4]江苏省非编码RNA基础与临床转化重点实验室,江苏扬州225009

出　　处：《现代中药研究与实践》2021年第3期93-97,共5页Research and Practice on Chinese Medicines

基　　金：国家自然科学基金资助项目(81673736);扬州大学大学生科研创新计划项目(x20200782)。

摘　　要：三七花皂苷是三七花的主要活性成分之一,主要包括人参皂苷类和三七皂苷类,具有多种药理活性。离子通道是生物电活动的基础,在许多细胞活动中起着关键作用。近年来,研究发现三七花皂苷成分能够调控多种细胞离子通道,进而发挥不同的药理作用。现就三七花皂苷多种成分对细胞离子通道的不同作用特点及可能的机制予以综述,为三七花皂苷成分的深入研究和合理应用提供可靠的理论依据。Panax notoginseng flower saponins are one of the major active components of Panax notoginseng flowers,mainly including ginsenosides and notoginsenosides,and have a variety of pharmacological activities.Ion channels are the basis of bioelectric activity and play a key role in many cell activities.In recent years,studies have found that Panax notoginseng flower saponins can regulate a variety of cell ion channels,and then exert different pharmacological effects.The study summarizes the different features and possible mechanisms of the various components of Panax notoginseng flower saponins on cell ion channels,aiming to provide a reliable theoretical basis for the in-depth study and rational application of Panax notoginseng flower saponins.

关 键 词：三七花 皂苷单体 离子通道 药理作用 

分 类 号：R285.5[医药卫生—中药学]